Nitroso-redox balance: a key mechanism in the regulation of the myocardial function in health and disease

Given the close interaction between nitric oxide (NO) and reactive oxygen species (ROS) in biological systems and their especial relevance in regulating aspects of the cardiovascular physiology, the concept of “nitroso-redox balance” has arisen as a more comprehensive manner of interpreting the intr...

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Detalles Bibliográficos
Autores principales:	Dulce, Raúl Ariel, Gonzalez, Daniel R.
Formato:	Articulo Revision
Lenguaje:	Inglés
Publicado:	2018
Materias:	Bioquímica Nitroso-redox balance S-nitrosylation Myocardial contractility Calcium handling Oxidative stress Balance nitroso-redox S-nitrosilacion Contractilidad miocárdica Manejo de calcio Estrés oxidativo
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/127221 https://pmr.safisiol.org.ar/uploadsarchivos/vol_11_n_1_dulce_ra.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-127221
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Bioquímica Nitroso-redox balance S-nitrosylation Myocardial contractility Calcium handling Oxidative stress Balance nitroso-redox S-nitrosilacion Contractilidad miocárdica Manejo de calcio Estrés oxidativo
spellingShingle	Bioquímica Nitroso-redox balance S-nitrosylation Myocardial contractility Calcium handling Oxidative stress Balance nitroso-redox S-nitrosilacion Contractilidad miocárdica Manejo de calcio Estrés oxidativo Dulce, Raúl Ariel Gonzalez, Daniel R. Nitroso-redox balance: a key mechanism in the regulation of the myocardial function in health and disease
topic_facet	Bioquímica Nitroso-redox balance S-nitrosylation Myocardial contractility Calcium handling Oxidative stress Balance nitroso-redox S-nitrosilacion Contractilidad miocárdica Manejo de calcio Estrés oxidativo
description	Given the close interaction between nitric oxide (NO) and reactive oxygen species (ROS) in biological systems and their especial relevance in regulating aspects of the cardiovascular physiology, the concept of “nitroso-redox balance” has arisen as a more comprehensive manner of interpreting the intracellular redox state. Nitroso-redox signaling pathways participate in numerous cardiovascular mechanisms, including myocardial contractility and relaxation, mitochondrial respiration, and endothelial function. Alterations of this balance are involved in numerous aspects of cardiovascular pathophysiology. NO and ROS generating mechanisms play a major role in both regulating and responding to the redox state of the cell, which targets calcium handling, contractile and vasoactive mechanisms. Thus, the nitroso-redox signaling pathway is critically important in cardiac physiology and pathophysiology, and consequently a fundamental therapeutic target. This article briefly addresses the cardiovascular implications of the biological balance between NO and ROS, and their relevance in the development of heart diseases.
format	Articulo Revision
author	Dulce, Raúl Ariel Gonzalez, Daniel R.
author_facet	Dulce, Raúl Ariel Gonzalez, Daniel R.
author_sort	Dulce, Raúl Ariel
title	Nitroso-redox balance: a key mechanism in the regulation of the myocardial function in health and disease
title_short	Nitroso-redox balance: a key mechanism in the regulation of the myocardial function in health and disease
title_full	Nitroso-redox balance: a key mechanism in the regulation of the myocardial function in health and disease
title_fullStr	Nitroso-redox balance: a key mechanism in the regulation of the myocardial function in health and disease
title_full_unstemmed	Nitroso-redox balance: a key mechanism in the regulation of the myocardial function in health and disease
title_sort	nitroso-redox balance: a key mechanism in the regulation of the myocardial function in health and disease
publishDate	2018
url	http://sedici.unlp.edu.ar/handle/10915/127221 https://pmr.safisiol.org.ar/uploadsarchivos/vol_11_n_1_dulce_ra.pdf
work_keys_str_mv	AT dulceraulariel nitrosoredoxbalanceakeymechanismintheregulationofthemyocardialfunctioninhealthanddisease AT gonzalezdanielr nitrosoredoxbalanceakeymechanismintheregulationofthemyocardialfunctioninhealthanddisease
bdutipo_str	Repositorios
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Nitroso-redox balance: a key mechanism in the regulation of the myocardial function in health and disease

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