Variation in dental morphology and inference of continental ancestry in admixed Latin Americans

Objectives: To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans.; Materials and Methods: We characterized a sample from Colombia (N = 477) for 34 dental traits and obta...

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Detalles Bibliográficos
Autores principales: Delgado Burbano, Miguel Eduardo, Ramírez, Luis, Adhikari, Kaustubh, Fuentes Guajardo, Macarena, Zanolli, Clément, González José, Rolando, Canizales, Samuel, Bortolini, Maria Cátira, Poletti, Giovanni, Gallo, Carla, Rothhammer, Francisco, Bedoya, Gabriel, Ruiz Linares, Andrés
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2019
Materias:
Antropología
Dental morphology
Admixture
Ancestry inference
Latin America
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127160
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127160
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Antropología
Dental morphology
Admixture
Ancestry inference
Latin America
spellingShingle Antropología
Dental morphology
Admixture
Ancestry inference
Latin America
Delgado Burbano, Miguel Eduardo
Ramírez, Luis
Adhikari, Kaustubh
Fuentes Guajardo, Macarena
Zanolli, Clément
González José, Rolando
Canizales, Samuel
Bortolini, Maria Cátira
Poletti, Giovanni
Gallo, Carla
Rothhammer, Francisco
Bedoya, Gabriel
Ruiz Linares, Andrés
Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
topic_facet Antropología
Dental morphology
Admixture
Ancestry inference
Latin America
description Objectives: To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans.; Materials and Methods: We characterized a sample from Colombia (N = 477) for 34 dental traits and obtained estimates of individual Native American, European, and African ancestry using genome‐wide SNP data. We tested for correlation between dental traits, genetic ancestry, age, and sex. We carried out a biodistance analysis between the Colombian sample and reference continental population samples using the mean measure of divergence statistic calculated from dental trait frequencies. We evaluated the inference of genetic ancestry from dental traits using a regression approach (with 10‐fold cross‐validation) as well as by testing the correlation between estimates of ancestry obtained from genetic and dental data.; Results: Latin Americans show intermediate dental trait frequencies when compared to Native Americans, Europeans, and Africans. Significant correlations were observed for several dental traits, genetic ancestry, age, and sex. The biodistance analysis displayed a closer relationship of Colombians to Europeans than to Native Americans and Africans. Mean ancestry estimates obtained from the dental data are similar to the genetic estimates (Native American: 32% vs. 28%, European: 59% vs. 63%, and African: 9% vs. 9%, respectively). However, dental features provided low predictive power for genetic ancestry of individuals in both approaches tested (R2 < 5% for all genetic ancestries across methods).; Discussion: The frequency of dental traits in Latin Americans reflects their admixed Native American, European and African ancestry and can provide reasonable average estimates of genetic ancestry. However, the accuracy of individual genetic ancestry estimates is relatively low, probably influenced by the continental differentiation of dental traits, their genetic architecture, and the distribution of genetic ancestry in the individuals examined.
format Articulo
Preprint
author Delgado Burbano, Miguel Eduardo
Ramírez, Luis
Adhikari, Kaustubh
Fuentes Guajardo, Macarena
Zanolli, Clément
González José, Rolando
Canizales, Samuel
Bortolini, Maria Cátira
Poletti, Giovanni
Gallo, Carla
Rothhammer, Francisco
Bedoya, Gabriel
Ruiz Linares, Andrés
author_facet Delgado Burbano, Miguel Eduardo
Ramírez, Luis
Adhikari, Kaustubh
Fuentes Guajardo, Macarena
Zanolli, Clément
González José, Rolando
Canizales, Samuel
Bortolini, Maria Cátira
Poletti, Giovanni
Gallo, Carla
Rothhammer, Francisco
Bedoya, Gabriel
Ruiz Linares, Andrés
author_sort Delgado Burbano, Miguel Eduardo
title Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
title_short Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
title_full Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
title_fullStr Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
title_full_unstemmed Variation in dental morphology and inference of continental ancestry in admixed Latin Americans
title_sort variation in dental morphology and inference of continental ancestry in admixed latin americans
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/127160
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