The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin

Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. It consists of a nonapeptide component coupled to the ion zinc, which confers biological activity to the molecule. After its discovery in the early 1970s, thymulin was characterized as a thymic hormone involved in seve...

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Autores principales:	Reggiani, Paula Cecilia, Morel, Gustavo Ramón, Console de Avegliano, Gloria Miriam, Barbeito, Claudio Gustavo, Rodríguez, Silvia Susana, Brown, Oscar Alfredo, Bellini, María José, Pleau, Jean-Marie, Dardenne, Mireille, Goya, Rodolfo Gustavo
Formato:	Articulo Preprint
Lenguaje:	Inglés
Publicado:	2009
Materias:	Ciencias Médicas Thymulin Neuroendocrine control Hypophysiotropic activity Artificial gene Gene therapy Antiinflammatory Ovarian dysgenesis
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/127133
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-127133
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Thymulin Neuroendocrine control Hypophysiotropic activity Artificial gene Gene therapy Antiinflammatory Ovarian dysgenesis
spellingShingle	Ciencias Médicas Thymulin Neuroendocrine control Hypophysiotropic activity Artificial gene Gene therapy Antiinflammatory Ovarian dysgenesis Reggiani, Paula Cecilia Morel, Gustavo Ramón Console de Avegliano, Gloria Miriam Barbeito, Claudio Gustavo Rodríguez, Silvia Susana Brown, Oscar Alfredo Bellini, María José Pleau, Jean-Marie Dardenne, Mireille Goya, Rodolfo Gustavo The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin
topic_facet	Ciencias Médicas Thymulin Neuroendocrine control Hypophysiotropic activity Artificial gene Gene therapy Antiinflammatory Ovarian dysgenesis
description	Thymulin is a thymic hormone exclusively produced by the thymic epithelial cells. It consists of a nonapeptide component coupled to the ion zinc, which confers biological activity to the molecule. After its discovery in the early 1970s, thymulin was characterized as a thymic hormone involved in several aspects of intrathymic and extrathymic T cell differentiation. Subsequently, it was demonstrated that thymulin production and secretion is strongly influenced by the neuroendocrine system. Conversely, a growing core of information, to be reviewed here, points to thymulin as a hypophysotropic peptide. In recent years, interest has arisen in the potential use of thymulin as a therapeutic agent. Thymulin was shown to possess anti-inflammatory and analgesic properties in the brain. Furthermore, an adenoviral vector harboring a synthetic gene for thymulin, stereotaxically injected in the rat brain, achieved a much longer expression than the adenovirally mediated expression in the brain of other genes, thus suggesting that an anti-inflammatory activity of thymulin prevents the immune system from destroying virus-transduced brain cells. Other studies suggest that thymulin gene therapy may also be a suitable therapeutic strategy to prevent some of the endocrine and metabolic alterations that typically appear in thymus-deficient animal models. The present article briefly reviews the literature on the physiology, molecular biology, and therapeutic potential of thymulin.
format	Articulo Preprint
author	Reggiani, Paula Cecilia Morel, Gustavo Ramón Console de Avegliano, Gloria Miriam Barbeito, Claudio Gustavo Rodríguez, Silvia Susana Brown, Oscar Alfredo Bellini, María José Pleau, Jean-Marie Dardenne, Mireille Goya, Rodolfo Gustavo
author_facet	Reggiani, Paula Cecilia Morel, Gustavo Ramón Console de Avegliano, Gloria Miriam Barbeito, Claudio Gustavo Rodríguez, Silvia Susana Brown, Oscar Alfredo Bellini, María José Pleau, Jean-Marie Dardenne, Mireille Goya, Rodolfo Gustavo
author_sort	Reggiani, Paula Cecilia
title	The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin
title_short	The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin
title_full	The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin
title_fullStr	The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin
title_full_unstemmed	The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin
title_sort	thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin
publishDate	2009
url	http://sedici.unlp.edu.ar/handle/10915/127133
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The thymus-neuroendocrine axis: physiology, molecular biology, and therapeutic potential of the thymic peptide thymulin

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