Computer-Aided Identification of Anticonvulsant Effect of Natural Nonnutritive Sweeteners Stevioside and Rebaudioside A

Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert. (Asteraceae) that have recently gained worldwide approval as nonnutritive sweeteners by the Joint Food and Agriculture Organization/World Organization Expert Committee on Food Additives. Cheminformatic tools suggested tha...

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Detalles Bibliográficos
Autores principales: Di Ianni, Mauricio Emiliano, Valle, María Elena del, Enrique, Andrea Verónica, Rosella, María Adelaida, Bruno, Fiorella Gianina, Bruno Blanch, Luis Enrique, Talevi, Alan
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Biología
Rebaudioside A
Stevioside
Stevia rebaudiana
Pharmacology
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/127131
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-127131
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Rebaudioside A
Stevioside
Stevia rebaudiana
Pharmacology
spellingShingle Biología
Rebaudioside A
Stevioside
Stevia rebaudiana
Pharmacology
Di Ianni, Mauricio Emiliano
Valle, María Elena del
Enrique, Andrea Verónica
Rosella, María Adelaida
Bruno, Fiorella Gianina
Bruno Blanch, Luis Enrique
Talevi, Alan
Computer-Aided Identification of Anticonvulsant Effect of Natural Nonnutritive Sweeteners Stevioside and Rebaudioside A
topic_facet Biología
Rebaudioside A
Stevioside
Stevia rebaudiana
Pharmacology
description Steviol glycosides are natural constituents of Stevia rebaudiana (Bert.) Bert. (Asteraceae) that have recently gained worldwide approval as nonnutritive sweeteners by the Joint Food and Agriculture Organization/World Organization Expert Committee on Food Additives. Cheminformatic tools suggested that the aglycone steviol and several of its phase I metabolites were predicted as potential anticonvulsant agents effective in the seizure animal model maximal electroshock seizure (MES) test. Thus, aqueous infusion from S. rebaudiana was tested in the MES test (mice, intraperitoneal administration), confirming dose-dependent anticonvulsant effect. Afterward, isolated stevioside and rebaudioside A were tested in the MES test, with positive results. Though drug repositioning most often focuses on known therapeutics, this article illustrates the possibilities of this strategy to find new functionalities and therapeutic indications for food constituents and natural products.
format Articulo
Articulo
author Di Ianni, Mauricio Emiliano
Valle, María Elena del
Enrique, Andrea Verónica
Rosella, María Adelaida
Bruno, Fiorella Gianina
Bruno Blanch, Luis Enrique
Talevi, Alan
author_facet Di Ianni, Mauricio Emiliano
Valle, María Elena del
Enrique, Andrea Verónica
Rosella, María Adelaida
Bruno, Fiorella Gianina
Bruno Blanch, Luis Enrique
Talevi, Alan
author_sort Di Ianni, Mauricio Emiliano
title Computer-Aided Identification of Anticonvulsant Effect of Natural Nonnutritive Sweeteners Stevioside and Rebaudioside A
title_short Computer-Aided Identification of Anticonvulsant Effect of Natural Nonnutritive Sweeteners Stevioside and Rebaudioside A
title_full Computer-Aided Identification of Anticonvulsant Effect of Natural Nonnutritive Sweeteners Stevioside and Rebaudioside A
title_fullStr Computer-Aided Identification of Anticonvulsant Effect of Natural Nonnutritive Sweeteners Stevioside and Rebaudioside A
title_full_unstemmed Computer-Aided Identification of Anticonvulsant Effect of Natural Nonnutritive Sweeteners Stevioside and Rebaudioside A
title_sort computer-aided identification of anticonvulsant effect of natural nonnutritive sweeteners stevioside and rebaudioside a
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/127131
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