Deranged sodium to sudden death
In February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes th...
Guardado en:
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Articulo |
Lenguaje: | Inglés |
Publicado: |
2015
|
Materias: | |
Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/127083 |
Aporte de: |
id |
I19-R120-10915-127083 |
---|---|
record_format |
dspace |
institution |
Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
collection |
SEDICI (UNLP) |
language |
Inglés |
topic |
Ciencias Médicas Neuroscience Extramural Cardiac disorders Sudden death Sodium channel Sodium Homeostasis Medicine |
spellingShingle |
Ciencias Médicas Neuroscience Extramural Cardiac disorders Sudden death Sodium channel Sodium Homeostasis Medicine Clancy, Colleen E. Chen-Izu, Ye Bers, Donald M. Belardinelli, Luiz Boyden, Penelope A. Csernoch, Laszlo Despa, Sanda Fermini, Bernard Hool, Livia C. Izu, Leighton Kass, Robert S. Lederer, W. Jonathan Louch, William E. Maack, Christoph Mattiazzi, Alicia Ramona Qu, Zhilin Rajamani, Sridharan Rippinger, Crystal M. Sejersted, Ole M. O’Rourke, Brian Weiss, James N. Varró, Andras Zaza, Antonio Deranged sodium to sudden death |
topic_facet |
Ciencias Médicas Neuroscience Extramural Cardiac disorders Sudden death Sodium channel Sodium Homeostasis Medicine |
description |
In February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes the topics of presentation and discussion from the symposium, with a focus on the role of aberrant sodium channels and abnormal sodium homeostasis in cardiac arrhythmias and pharmacotherapy from the subcellular scale to the whole heart. Two following papers focus on Na⁺ channel structure, function and regulation, and Na⁺/Ca²⁺ exchange and Na⁺/K⁺ ATPase. The UC Davis Cardiovascular Symposium is a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The focus on Na⁺ in the 2014 symposium stemmed from the multitude of recent studies that point to the importance of maintaining Na⁺ homeostasis in the heart, as disruption of homeostatic processes are increasingly identified in cardiac disease states. Understanding how disruption in cardiac Na⁺-based processes leads to derangement in multiple cardiac components at the level of the cell and to then connect these perturbations to emergent behaviour in the heart to cause disease is a critical area of research. The ubiquity of disruption of Na⁺ channels and Na⁺ homeostasis in cardiac disorders of excitability and mechanics emphasizes the importance of a fundamental understanding of the associated mechanisms and disease processes to ultimately reveal new targets for human therapy. |
format |
Articulo Articulo |
author |
Clancy, Colleen E. Chen-Izu, Ye Bers, Donald M. Belardinelli, Luiz Boyden, Penelope A. Csernoch, Laszlo Despa, Sanda Fermini, Bernard Hool, Livia C. Izu, Leighton Kass, Robert S. Lederer, W. Jonathan Louch, William E. Maack, Christoph Mattiazzi, Alicia Ramona Qu, Zhilin Rajamani, Sridharan Rippinger, Crystal M. Sejersted, Ole M. O’Rourke, Brian Weiss, James N. Varró, Andras Zaza, Antonio |
author_facet |
Clancy, Colleen E. Chen-Izu, Ye Bers, Donald M. Belardinelli, Luiz Boyden, Penelope A. Csernoch, Laszlo Despa, Sanda Fermini, Bernard Hool, Livia C. Izu, Leighton Kass, Robert S. Lederer, W. Jonathan Louch, William E. Maack, Christoph Mattiazzi, Alicia Ramona Qu, Zhilin Rajamani, Sridharan Rippinger, Crystal M. Sejersted, Ole M. O’Rourke, Brian Weiss, James N. Varró, Andras Zaza, Antonio |
author_sort |
Clancy, Colleen E. |
title |
Deranged sodium to sudden death |
title_short |
Deranged sodium to sudden death |
title_full |
Deranged sodium to sudden death |
title_fullStr |
Deranged sodium to sudden death |
title_full_unstemmed |
Deranged sodium to sudden death |
title_sort |
deranged sodium to sudden death |
publishDate |
2015 |
url |
http://sedici.unlp.edu.ar/handle/10915/127083 |
work_keys_str_mv |
AT clancycolleene derangedsodiumtosuddendeath AT chenizuye derangedsodiumtosuddendeath AT bersdonaldm derangedsodiumtosuddendeath AT belardinelliluiz derangedsodiumtosuddendeath AT boydenpenelopea derangedsodiumtosuddendeath AT csernochlaszlo derangedsodiumtosuddendeath AT despasanda derangedsodiumtosuddendeath AT ferminibernard derangedsodiumtosuddendeath AT hoolliviac derangedsodiumtosuddendeath AT izuleighton derangedsodiumtosuddendeath AT kassroberts derangedsodiumtosuddendeath AT ledererwjonathan derangedsodiumtosuddendeath AT louchwilliame derangedsodiumtosuddendeath AT maackchristoph derangedsodiumtosuddendeath AT mattiazzialiciaramona derangedsodiumtosuddendeath AT quzhilin derangedsodiumtosuddendeath AT rajamanisridharan derangedsodiumtosuddendeath AT rippingercrystalm derangedsodiumtosuddendeath AT sejerstedolem derangedsodiumtosuddendeath AT orourkebrian derangedsodiumtosuddendeath AT weissjamesn derangedsodiumtosuddendeath AT varroandras derangedsodiumtosuddendeath AT zazaantonio derangedsodiumtosuddendeath |
bdutipo_str |
Repositorios |
_version_ |
1764820451262988288 |