Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina

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We are at the dawn of the efforts to describe and understand the origins of genetic diversity in Argentina from high-throughput data. This knowledge is a primary step in the intent of deciphering the specific genetic bases of diseases and drug response in the country. Similarly to other populations...

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Autores principales: Luisi, Pierre, García, Angelina, Berros, Juan Manuel, Motti, Josefina María Brenda, Demarchi, Darío Alfredo, Alfaro, Emma, Aquilano, Eliana, Argüelles, Carina Francisca, Avena, Sergio Alejandro, Bailliet, Graciela, Beltramo, Julieta, Bravi, Claudio Marcelo, Cuello, Mariela Vanesa, Dejean, Cristina Beatriz, Dipierri, José Edgardo, Jurado Medina, Laura Smeldy, Lanata, José Luis, Muzzio, Marina, Parolín, María Laura, Pauro, Maia, Paz Sepúlveda, Paula Beatriz, Rodríguez Golpe, Daniela, Santos, María Rita, Schwab, Marisol Elisabet, Silvero, Natalia, Zubrzycki, Jeremías, Ramallo, Virginia, Dopazo, Hernán
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2020
Materias:
Ciencias Naturales
Ciencias Exactas
Genotype
Geography
Population
Genotyping
Genetic structure
Demographic history
Scale (social sciences)
Genetic genealogy
Evolutionary biology
Genetic diversity
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/126416
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-126416
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Naturales
Ciencias Exactas
Genotype
Geography
Population
Genotyping
Genetic structure
Demographic history
Scale (social sciences)
Genetic genealogy
Evolutionary biology
Genetic diversity
spellingShingle Ciencias Naturales
Ciencias Exactas
Genotype
Geography
Population
Genotyping
Genetic structure
Demographic history
Scale (social sciences)
Genetic genealogy
Evolutionary biology
Genetic diversity
Luisi, Pierre
García, Angelina
Berros, Juan Manuel
Motti, Josefina María Brenda
Demarchi, Darío Alfredo
Alfaro, Emma
Aquilano, Eliana
Argüelles, Carina Francisca
Avena, Sergio Alejandro
Bailliet, Graciela
Beltramo, Julieta
Bravi, Claudio Marcelo
Cuello, Mariela Vanesa
Dejean, Cristina Beatriz
Dipierri, José Edgardo
Jurado Medina, Laura Smeldy
Lanata, José Luis
Muzzio, Marina
Parolín, María Laura
Pauro, Maia
Paz Sepúlveda, Paula Beatriz
Rodríguez Golpe, Daniela
Santos, María Rita
Schwab, Marisol Elisabet
Silvero, Natalia
Zubrzycki, Jeremías
Ramallo, Virginia
Dopazo, Hernán
Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
topic_facet Ciencias Naturales
Ciencias Exactas
Genotype
Geography
Population
Genotyping
Genetic structure
Demographic history
Scale (social sciences)
Genetic genealogy
Evolutionary biology
Genetic diversity
description We are at the dawn of the efforts to describe and understand the origins of genetic diversity in Argentina from high-throughput data. This knowledge is a primary step in the intent of deciphering the specific genetic bases of diseases and drug response in the country. Similarly to other populations across the Americas, genetic ancestry in Argentinean populations traces back into African, European and Native American ancestors, reflecting a complex demographic history with multiple migration and admixture events in pre- and post-colonial times. However, little is known about the sub-continental origins of these three main ancestries. We present new high-throughput genotyping data for 87 admixed individuals across Argentina. This data was combined to previously published data for admixed individuals in the region and then compared to different reference panels specifically built to run population structure analyses at a sub-continental level. Concerning the European and African ancestries, we confirmed previous results about their main origins, and we provide new insights into the presence of other origins that reflect historical records. As for the Native American ancestry, leveraging genotype data for archeological samples in the region in order to gain temporal depth in our analyses, we could identify four Native American components segregating in modern Argentinean populations . Three of them are also found in modern South American populations and are specifically represented in Central Chile/Patagonia, Lowlands and Central Andes geographic areas. The fourth one may be specific to the Central Western region of Argentina. Identifying such component has not been straightforward since it is not well represented in any genomic data from the literature. Altogether, we provide useful insights into the multiple population groups from different continents that have contributed to present-days genetic diversity in Argentina. We encourage the generation of massive genotype data locally to further describe the genetic structure in Argentina.
format Articulo
Preprint
author Luisi, Pierre
García, Angelina
Berros, Juan Manuel
Motti, Josefina María Brenda
Demarchi, Darío Alfredo
Alfaro, Emma
Aquilano, Eliana
Argüelles, Carina Francisca
Avena, Sergio Alejandro
Bailliet, Graciela
Beltramo, Julieta
Bravi, Claudio Marcelo
Cuello, Mariela Vanesa
Dejean, Cristina Beatriz
Dipierri, José Edgardo
Jurado Medina, Laura Smeldy
Lanata, José Luis
Muzzio, Marina
Parolín, María Laura
Pauro, Maia
Paz Sepúlveda, Paula Beatriz
Rodríguez Golpe, Daniela
Santos, María Rita
Schwab, Marisol Elisabet
Silvero, Natalia
Zubrzycki, Jeremías
Ramallo, Virginia
Dopazo, Hernán
author_facet Luisi, Pierre
García, Angelina
Berros, Juan Manuel
Motti, Josefina María Brenda
Demarchi, Darío Alfredo
Alfaro, Emma
Aquilano, Eliana
Argüelles, Carina Francisca
Avena, Sergio Alejandro
Bailliet, Graciela
Beltramo, Julieta
Bravi, Claudio Marcelo
Cuello, Mariela Vanesa
Dejean, Cristina Beatriz
Dipierri, José Edgardo
Jurado Medina, Laura Smeldy
Lanata, José Luis
Muzzio, Marina
Parolín, María Laura
Pauro, Maia
Paz Sepúlveda, Paula Beatriz
Rodríguez Golpe, Daniela
Santos, María Rita
Schwab, Marisol Elisabet
Silvero, Natalia
Zubrzycki, Jeremías
Ramallo, Virginia
Dopazo, Hernán
author_sort Luisi, Pierre
title Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
title_short Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
title_full Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
title_fullStr Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
title_full_unstemmed Fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in Argentina
title_sort fine-scale genomic analyses of admixed individuals reveal unrecognized genetic ancestry components in argentina
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/126416
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