Risk factors for COVID-19 mortality: The effect of convalescent plasma administration

Background: Convalescent plasma, widely utilized in viral infections that induce neutralizing antibodies, has been proposed for COVID-19, and preliminary evidence shows that it might have beneficial effect. Our objective was to determine the risk factors for 28-days mortality in patients who receive...

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Autores principales: Salazar, Martín R., González, Soledad E., Regairaz, Lorena, Ferrando, Noelia Soledad, González Martínez, Verónica G., Carrera Ramos, Patricia M., Muñoz, Laura, Pesci, Santiago A., Vidal, Juan M., Kreplak, Nicolás, Estenssoro, Elisa
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Medicina
COVID-19
Risk factors
Plasma administration
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/126277
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-126277
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
COVID-19
Risk factors
Plasma administration
spellingShingle Medicina
COVID-19
Risk factors
Plasma administration
Salazar, Martín R.
González, Soledad E.
Regairaz, Lorena
Ferrando, Noelia Soledad
González Martínez, Verónica G.
Carrera Ramos, Patricia M.
Muñoz, Laura
Pesci, Santiago A.
Vidal, Juan M.
Kreplak, Nicolás
Estenssoro, Elisa
Risk factors for COVID-19 mortality: The effect of convalescent plasma administration
topic_facet Medicina
COVID-19
Risk factors
Plasma administration
description Background: Convalescent plasma, widely utilized in viral infections that induce neutralizing antibodies, has been proposed for COVID-19, and preliminary evidence shows that it might have beneficial effect. Our objective was to determine the risk factors for 28-days mortality in patients who received convalescent plasma for COVID-19 compared to those who did not, who were admitted to hospitals in Buenos Aires Province, Argentina, throughout the pandemic. Methods: This is a multicenter, retrospective cohort study of 2-month duration beginning on June 1, 2020, including unselected, consecutive adult patients with diagnosed COVID-19, admitted to 215 hospitals with pneumonia. Epidemiological and clinical variables were registered in the Provincial Hospital Bed Management System. Convalescent plasma was supplied as part of a centralized, expanded access program. Results: We analyzed 3,529 patients with pneumonia, predominantly male, aged 62±17, with arterial hypertension and diabetes as main comorbidities; 51.4% were admitted to the ward, 27.1% to the Intensive Care Unit (ICU), and 21.7% to the ICU with mechanical ventilation requirement (ICU-MV). 28-day mortality was 34.9%; and was 26.3%, 30.1% and 61.4% for ward, ICU and ICU-MV patients. Convalescent plasma was administered to 868 patients (24.6%); their 28-day mortality was significantly lower (25.5% vs. 38.0%, p<0.001). No major adverse effects occurred. Logistic regression analysis identified age, ICU admission with and without MV requirement, diabetes, and preexistent cardiovascular disease as independent predictors of 28-day mortality, whereas convalescent plasma administration acted as a protective factor. Conclusions: Our study suggests that the administration of convalescent plasma in COVID-19 pneumonia admitted to the hospital might be associated with improved outcomes.
format Articulo
Articulo
author Salazar, Martín R.
González, Soledad E.
Regairaz, Lorena
Ferrando, Noelia Soledad
González Martínez, Verónica G.
Carrera Ramos, Patricia M.
Muñoz, Laura
Pesci, Santiago A.
Vidal, Juan M.
Kreplak, Nicolás
Estenssoro, Elisa
author_facet Salazar, Martín R.
González, Soledad E.
Regairaz, Lorena
Ferrando, Noelia Soledad
González Martínez, Verónica G.
Carrera Ramos, Patricia M.
Muñoz, Laura
Pesci, Santiago A.
Vidal, Juan M.
Kreplak, Nicolás
Estenssoro, Elisa
author_sort Salazar, Martín R.
title Risk factors for COVID-19 mortality: The effect of convalescent plasma administration
title_short Risk factors for COVID-19 mortality: The effect of convalescent plasma administration
title_full Risk factors for COVID-19 mortality: The effect of convalescent plasma administration
title_fullStr Risk factors for COVID-19 mortality: The effect of convalescent plasma administration
title_full_unstemmed Risk factors for COVID-19 mortality: The effect of convalescent plasma administration
title_sort risk factors for covid-19 mortality: the effect of convalescent plasma administration
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/126277
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