Oxidative stress in fetal programming of cardiometabolic syndrome

Cardiometabolic syndrome (CMS) is now a disease entity recognized by the World Health Organization. Emerging evidence from both human epidemiological and animal studies indicates that adult CMS may have its origins in early life and can be programmed by intrauterine and early postnatal environments;...

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Autores principales: Chao, Yung-Mei, Chan, Julie Y.H.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Ciencias Médicas
Fetal programming
Oxidative stress
Cardiometabolic syndrome
Reprogramming therapy
Antioxidants
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/126221
https://pmr.safisiol.org.ar/archive/id/119
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-126221
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Fetal programming
Oxidative stress
Cardiometabolic syndrome
Reprogramming therapy
Antioxidants
spellingShingle Ciencias Médicas
Fetal programming
Oxidative stress
Cardiometabolic syndrome
Reprogramming therapy
Antioxidants
Chao, Yung-Mei
Chan, Julie Y.H.
Oxidative stress in fetal programming of cardiometabolic syndrome
topic_facet Ciencias Médicas
Fetal programming
Oxidative stress
Cardiometabolic syndrome
Reprogramming therapy
Antioxidants
description Cardiometabolic syndrome (CMS) is now a disease entity recognized by the World Health Organization. Emerging evidence from both human epidemiological and animal studies indicates that adult CMS may have its origins in early life and can be programmed by intrauterine and early postnatal environments; a phenomenon known as fetal programming of adult disease. This mini-review discusses [1]how exposures to various insults from the mother during gestation and/or lactation programs the fetus that prompts the development of CMS during adulthood; [2] what are the currently known underlying mechanisms, with emphasis on the role of tissue oxidative stress; and [3] whether CMS in the offspring can be reprogrammed via targeting maternal tissue oxidative stress. Translational perspective of the research field is also discussed.
format Articulo
Articulo
author Chao, Yung-Mei
Chan, Julie Y.H.
author_facet Chao, Yung-Mei
Chan, Julie Y.H.
author_sort Chao, Yung-Mei
title Oxidative stress in fetal programming of cardiometabolic syndrome
title_short Oxidative stress in fetal programming of cardiometabolic syndrome
title_full Oxidative stress in fetal programming of cardiometabolic syndrome
title_fullStr Oxidative stress in fetal programming of cardiometabolic syndrome
title_full_unstemmed Oxidative stress in fetal programming of cardiometabolic syndrome
title_sort oxidative stress in fetal programming of cardiometabolic syndrome
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/126221
https://pmr.safisiol.org.ar/archive/id/119
work_keys_str_mv AT chaoyungmei oxidativestressinfetalprogrammingofcardiometabolicsyndrome
AT chanjulieyh oxidativestressinfetalprogrammingofcardiometabolicsyndrome
bdutipo_str Repositorios
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