Motor neuron loss in aging and amyotrophic lateral sclerosis: different fuse lengths, same explosion

Advanced age and amyotrophic lateral sclerosis (ALS) are both associated with a loss of motor neurons resulting in muscle fiber atrophy and muscle weakness. Aging associated muscle fiber atrophy and weakening is termed sarcopenia, but the association with motor neuron loss is not as clearly establis...

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Detalles Bibliográficos
Autores principales: Fogarty, Matthew J., Brown, Alyssa D., Sieck, Gary C.
Formato: Articulo
Lenguaje:Español
Publicado: 2020
Materias:
Ciencias Médicas
Motor neurons
Diaphragm muscle
Mitocondria
Neuronas motoras
Músculo diafragma
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/126217
https://pmr.safisiol.org.ar/archive/id/116
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-126217
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Médicas
Motor neurons
Diaphragm muscle
Mitocondria
Neuronas motoras
Músculo diafragma
Mitocondria
spellingShingle Ciencias Médicas
Motor neurons
Diaphragm muscle
Mitocondria
Neuronas motoras
Músculo diafragma
Mitocondria
Fogarty, Matthew J.
Brown, Alyssa D.
Sieck, Gary C.
Motor neuron loss in aging and amyotrophic lateral sclerosis: different fuse lengths, same explosion
topic_facet Ciencias Médicas
Motor neurons
Diaphragm muscle
Mitocondria
Neuronas motoras
Músculo diafragma
Mitocondria
description Advanced age and amyotrophic lateral sclerosis (ALS) are both associated with a loss of motor neurons resulting in muscle fiber atrophy and muscle weakness. Aging associated muscle fiber atrophy and weakening is termed sarcopenia, but the association with motor neuron loss is not as clearly established as in ALS, probably related to the prolonged time course of aging-related changes. Although aging and ALS effects on limb muscle strength and neuromotor performance are serious, such effects on the diaphragm muscle can be life threatening. Converging evidence indicates that larger phrenic motor neurons, innervating more fatigable type IIx and/or IIb diaphragm muscle fibers (fast fatigue intermediate, FInt and fast fatigable, FF motor units) are more susceptible to degeneration with both aging and ALS compared to smaller phrenic motor neurons innervating type I and IIa diaphragm muscle fibers (slow and fast fatigue resistant motor units, respectively). The etiology of ALS and age-related loss of motor neurons appears to involve mitochondrial function and neuroinflammation, both chronic and acute exacerbation. How mitochondrial dysfunction, neuroinflammation and motor neuron size intersect is the focus of continuing investigation.
format Articulo
Articulo
author Fogarty, Matthew J.
Brown, Alyssa D.
Sieck, Gary C.
author_facet Fogarty, Matthew J.
Brown, Alyssa D.
Sieck, Gary C.
author_sort Fogarty, Matthew J.
title Motor neuron loss in aging and amyotrophic lateral sclerosis: different fuse lengths, same explosion
title_short Motor neuron loss in aging and amyotrophic lateral sclerosis: different fuse lengths, same explosion
title_full Motor neuron loss in aging and amyotrophic lateral sclerosis: different fuse lengths, same explosion
title_fullStr Motor neuron loss in aging and amyotrophic lateral sclerosis: different fuse lengths, same explosion
title_full_unstemmed Motor neuron loss in aging and amyotrophic lateral sclerosis: different fuse lengths, same explosion
title_sort motor neuron loss in aging and amyotrophic lateral sclerosis: different fuse lengths, same explosion
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/126217
https://pmr.safisiol.org.ar/archive/id/116
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