Oxidative stress and cardiac contractility: a double edge sword?
The stretch of cardiac muscle increases developed force in two phases. The first phase occurs immediately after stretch and is the expression of the Frank–Starling mechanism, while the second one or slow force response (SFR) occurs gradually and is due to an increase in the calcium transient amplitu...
Guardado en:
| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2021
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/126212 https://pmr.safisiol.org.ar/archive/id/130 |
| Aporte de: |
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I19-R120-10915-126212 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas TRX1 SFR NHE1 Oxidative stress Cardiac hypertrophy Stress oxidativo Hipertrofia cardiaca |
| spellingShingle |
Ciencias Médicas TRX1 SFR NHE1 Oxidative stress Cardiac hypertrophy Stress oxidativo Hipertrofia cardiaca Zavala, Maite Raquel Díaz, Romina Gisel Pérez, Néstor Gustavo Villa Abrille, María Celeste Oxidative stress and cardiac contractility: a double edge sword? |
| topic_facet |
Ciencias Médicas TRX1 SFR NHE1 Oxidative stress Cardiac hypertrophy Stress oxidativo Hipertrofia cardiaca |
| description |
The stretch of cardiac muscle increases developed force in two phases. The first phase occurs immediately after stretch and is the expression of the Frank–Starling mechanism, while the second one or slow force response (SFR) occurs gradually and is due to an increase in the calcium transient amplitude. Previously, we have shown that the SFR is the mechanical manifestation of an autocrine/paracrine mechanism activated by wall stretch involving growth factors-triggered reactive oxygen species (ROS) formation, and followed by redox-mediated cardiac Na+/H+ exchanger (NHE1) activation leading to an increase in the Ca2+ "transient" amplitude. Recent own experiments assigned a role to thioredoxin-1 (“TRX1”, an important cellular antioxidant enzymatic system) in the development of the SFR. Interestingly, cardiac hypertrophy and failure, two of the most important health problems in western societies, are both triggered by intracellular signals triggered by myocardial stretch, being oxidative stress a critical step for its progression. Remarkably, experimental evidence has revealed that TRX1 overexpression negatively regulates cardiac hypertrophy. In this scenario, this short review was meant to briefly discuss the physiological, but potentially pathological, role of oxidative stress following myocardial stretch. |
| format |
Articulo Articulo |
| author |
Zavala, Maite Raquel Díaz, Romina Gisel Pérez, Néstor Gustavo Villa Abrille, María Celeste |
| author_facet |
Zavala, Maite Raquel Díaz, Romina Gisel Pérez, Néstor Gustavo Villa Abrille, María Celeste |
| author_sort |
Zavala, Maite Raquel |
| title |
Oxidative stress and cardiac contractility: a double edge sword? |
| title_short |
Oxidative stress and cardiac contractility: a double edge sword? |
| title_full |
Oxidative stress and cardiac contractility: a double edge sword? |
| title_fullStr |
Oxidative stress and cardiac contractility: a double edge sword? |
| title_full_unstemmed |
Oxidative stress and cardiac contractility: a double edge sword? |
| title_sort |
oxidative stress and cardiac contractility: a double edge sword? |
| publishDate |
2021 |
| url |
http://sedici.unlp.edu.ar/handle/10915/126212 https://pmr.safisiol.org.ar/archive/id/130 |
| work_keys_str_mv |
AT zavalamaiteraquel oxidativestressandcardiaccontractilityadoubleedgesword AT diazrominagisel oxidativestressandcardiaccontractilityadoubleedgesword AT pereznestorgustavo oxidativestressandcardiaccontractilityadoubleedgesword AT villaabrillemariaceleste oxidativestressandcardiaccontractilityadoubleedgesword |
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Repositorios |
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1764820450198683649 |