Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina

Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by inf...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Fabricius, Gabriel, Bergero, Paula Elena, Ormazabal, Maximiliano Emanuel, Maltz, Alberto Leonardo, Hozbor, Daniela Flavia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Biología
Epidemic
Mathematical model
Bordetella pertussis
Tdap booster
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/126189
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-126189
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Epidemic
Mathematical model
Bordetella pertussis
Tdap booster
spellingShingle Biología
Epidemic
Mathematical model
Bordetella pertussis
Tdap booster
Fabricius, Gabriel
Bergero, Paula Elena
Ormazabal, Maximiliano Emanuel
Maltz, Alberto Leonardo
Hozbor, Daniela Flavia
Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
topic_facet Biología
Epidemic
Mathematical model
Bordetella pertussis
Tdap booster
description Due to the current epidemiological situation of pertussis, several countries have implemented vaccination strategies that include a booster dose for adolescents. Since there is still no evidence showing that the adolescent booster has a positive effect on the most vulnerable group represented by infants, it is difficult to universalize the recommendation to include such reinforcement. In this work we present an age-structured compartmental deterministic model that considers the outstanding epidemiological features of the disease in order to assess the impact of the booster dose at age 11 years (Tdap booster) to infants. To this end, we performed different parameterizations of the model that represent distinct possible epidemiological scenarios. The results obtained show that the inclusion of a single Tdap dose at age 11 years significantly reduces the incidence of the disease within this age group, but has a very low impact on the risk group (0–1 year). An effort to improve the coverage of the first dose would have a much greater impact on infants. These results hold in the 18 scenarios considered, which demonstrates the robustness of these conclusions.
format Articulo
Articulo
author Fabricius, Gabriel
Bergero, Paula Elena
Ormazabal, Maximiliano Emanuel
Maltz, Alberto Leonardo
Hozbor, Daniela Flavia
author_facet Fabricius, Gabriel
Bergero, Paula Elena
Ormazabal, Maximiliano Emanuel
Maltz, Alberto Leonardo
Hozbor, Daniela Flavia
author_sort Fabricius, Gabriel
title Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_short Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_full Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_fullStr Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_full_unstemmed Modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in Argentina
title_sort modelling pertussis transmission to evaluate the effectiveness of an adolescent booster in argentina
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/126189
work_keys_str_mv AT fabriciusgabriel modellingpertussistransmissiontoevaluatetheeffectivenessofanadolescentboosterinargentina
AT bergeropaulaelena modellingpertussistransmissiontoevaluatetheeffectivenessofanadolescentboosterinargentina
AT ormazabalmaximilianoemanuel modellingpertussistransmissiontoevaluatetheeffectivenessofanadolescentboosterinargentina
AT maltzalbertoleonardo modellingpertussistransmissiontoevaluatetheeffectivenessofanadolescentboosterinargentina
AT hozbordanielaflavia modellingpertussistransmissiontoevaluatetheeffectivenessofanadolescentboosterinargentina
bdutipo_str Repositorios
_version_ 1764820450180857858

Ejemplares similares