Role of cooperative binding on noise expression

The origin of stochastic fluctuations in gene expression has received considerable attention recently. Fluctuations in gene expression are particularly pronounced in cellular systems because of the small copy number of species undergoing transitions between discrete chemical states and the small siz...

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Detalles Bibliográficos
Autores principales: Gutiérrez, Pablo S., Monteoliva, Diana, Diambra, Luis Aníbal
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Física
Binding site
Physics
Biophysics
Stochastic modelling
Formalism (philosophy of mathematics)
Gene expression
Regulation of gene expression
Cooperativity
Cooperative binding
Interaction energy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125947
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125947
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Física
Binding site
Physics
Biophysics
Stochastic modelling
Formalism (philosophy of mathematics)
Gene expression
Regulation of gene expression
Cooperativity
Cooperative binding
Interaction energy
spellingShingle Física
Binding site
Physics
Biophysics
Stochastic modelling
Formalism (philosophy of mathematics)
Gene expression
Regulation of gene expression
Cooperativity
Cooperative binding
Interaction energy
Gutiérrez, Pablo S.
Monteoliva, Diana
Diambra, Luis Aníbal
Role of cooperative binding on noise expression
topic_facet Física
Binding site
Physics
Biophysics
Stochastic modelling
Formalism (philosophy of mathematics)
Gene expression
Regulation of gene expression
Cooperativity
Cooperative binding
Interaction energy
description The origin of stochastic fluctuations in gene expression has received considerable attention recently. Fluctuations in gene expression are particularly pronounced in cellular systems because of the small copy number of species undergoing transitions between discrete chemical states and the small size of biological compartments. In this paper, we propose a stochastic model for gene expression regulation including several binding sites, considering elementary reactions only. The model is used to investigate the role of cooperativity on the intrinsic fluctuations of gene expression by means of master-equation formalism. We found that the Hill coefficient and the level of noise increase as the interaction energy between activators increases. Additionally, we show that the model allows one to distinguish between two cooperative binding mechanisms.
format Articulo
Articulo
author Gutiérrez, Pablo S.
Monteoliva, Diana
Diambra, Luis Aníbal
author_facet Gutiérrez, Pablo S.
Monteoliva, Diana
Diambra, Luis Aníbal
author_sort Gutiérrez, Pablo S.
title Role of cooperative binding on noise expression
title_short Role of cooperative binding on noise expression
title_full Role of cooperative binding on noise expression
title_fullStr Role of cooperative binding on noise expression
title_full_unstemmed Role of cooperative binding on noise expression
title_sort role of cooperative binding on noise expression
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/125947
work_keys_str_mv AT gutierrezpablos roleofcooperativebindingonnoiseexpression
AT monteolivadiana roleofcooperativebindingonnoiseexpression
AT diambraluisanibal roleofcooperativebindingonnoiseexpression
bdutipo_str Repositorios
_version_ 1764820452516036608

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