Fetoplacental endothelial dysfunction in maternal hypercholesterolemia and obesity in pregnancy

Human fetoplacental vascular function is altered in several pathologies of pregnancy as a result of endothelial dysfunction. Pregnancy is a physiological condition coursing with increased circulating plasma levels of cholesterol in the mother, to respond to the higher demands from the growing fetus....

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Autores principales:	Pardo, Fabián, Silva, Luis, Salsoso, Rocío, Sáez, Tamara, Farías, Marcelo, Villalobos, Roberto, Leiva, Andrea, Sanhueza, Carlos, Sobrevia, Luis
Formato:	Articulo Revision
Lenguaje:	Inglés
Publicado:	2014
Materias:	Ciencias Médicas Endothelial dysfunction Pregnancy
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/125642 https://pmr.safisiol.org.ar/archive/id/67
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-125642
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Endothelial dysfunction Pregnancy
spellingShingle	Ciencias Médicas Endothelial dysfunction Pregnancy Pardo, Fabián Silva, Luis Salsoso, Rocío Sáez, Tamara Farías, Marcelo Villalobos, Roberto Leiva, Andrea Sanhueza, Carlos Sobrevia, Luis Fetoplacental endothelial dysfunction in maternal hypercholesterolemia and obesity in pregnancy
topic_facet	Ciencias Médicas Endothelial dysfunction Pregnancy
description	Human fetoplacental vascular function is altered in several pathologies of pregnancy as a result of endothelial dysfunction. Pregnancy is a physiological condition coursing with increased circulating plasma levels of cholesterol in the mother, to respond to the higher demands from the growing fetus. An abnormal increase in maternal plasma cholesterol configures a pathological state referred as maternal supraphysiological hypercholesterolemia (MSPH). In MSPH, L-arginine transport and synthesis of nitric oxide (i.e., L-arginine/NO signalling pathway) as well as arginases/urea cycle in the fetoplacental endothelium are altered. Equally, an increase in the physiological gain of weight in pregnant women could end with obese women at the end of pregnancy leading to a condition referred as obesity in pregnancy (OP). OP seems to be also associated with alterations in the L-arginine/NO signalling pathway in endothelium in animal models; however, nothing is known regarding alterations of the human fetoplacental endothelium in OP. Insulin, adenosine and NO are vasodilators in the fetoplacental vascular bed, and a role for these molecules is proposed in MSPH and OP. Alternatively, involvement of intracellular pH modulation and the potential involvement of adenosine receptors is proposed as phenomena that could improve endothelial dysfunction associated with these diseases of pregnancy.
format	Articulo Revision
author	Pardo, Fabián Silva, Luis Salsoso, Rocío Sáez, Tamara Farías, Marcelo Villalobos, Roberto Leiva, Andrea Sanhueza, Carlos Sobrevia, Luis
author_facet	Pardo, Fabián Silva, Luis Salsoso, Rocío Sáez, Tamara Farías, Marcelo Villalobos, Roberto Leiva, Andrea Sanhueza, Carlos Sobrevia, Luis
author_sort	Pardo, Fabián
title	Fetoplacental endothelial dysfunction in maternal hypercholesterolemia and obesity in pregnancy
title_short	Fetoplacental endothelial dysfunction in maternal hypercholesterolemia and obesity in pregnancy
title_full	Fetoplacental endothelial dysfunction in maternal hypercholesterolemia and obesity in pregnancy
title_fullStr	Fetoplacental endothelial dysfunction in maternal hypercholesterolemia and obesity in pregnancy
title_full_unstemmed	Fetoplacental endothelial dysfunction in maternal hypercholesterolemia and obesity in pregnancy
title_sort	fetoplacental endothelial dysfunction in maternal hypercholesterolemia and obesity in pregnancy
publishDate	2014
url	http://sedici.unlp.edu.ar/handle/10915/125642 https://pmr.safisiol.org.ar/archive/id/67
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Fetoplacental endothelial dysfunction in maternal hypercholesterolemia and obesity in pregnancy

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