Vitamin D-VDR signaling in bone cells

Vitamin D plays a key role in mineral homeostasis, in which its main biological effect is to maintain adequate serum calcium levels. The systemic deficiency of either 1,25D or its receptor (VDR) is associated with bone alterations such as rickets and osteomalacia. This review summarizes the evidence...

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Autores principales: Braziunas, Marisol Denise, Cortizo, Ana María
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2014
Materias:
Ciencias Médicas
Vitamin D
Vitamin D receptor
Hydroxylases
Bone homeostasis
Bone marrow stromal cells
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125640
https://pmr.safisiol.org.ar/archive/id/71
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125640
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Vitamin D
Vitamin D receptor
Hydroxylases
Bone homeostasis
Bone marrow stromal cells
spellingShingle Ciencias Médicas
Vitamin D
Vitamin D receptor
Hydroxylases
Bone homeostasis
Bone marrow stromal cells
Braziunas, Marisol Denise
Cortizo, Ana María
Vitamin D-VDR signaling in bone cells
topic_facet Ciencias Médicas
Vitamin D
Vitamin D receptor
Hydroxylases
Bone homeostasis
Bone marrow stromal cells
description Vitamin D plays a key role in mineral homeostasis, in which its main biological effect is to maintain adequate serum calcium levels. The systemic deficiency of either 1,25D or its receptor (VDR) is associated with bone alterations such as rickets and osteomalacia. This review summarizes the evidence supporting a direct effect of vit D-VDR on bone cells. The presence of vit D-hydroxylases as well as VDR in several cell types, supports an autocrine / paracrine role for vitamin D. Bone-derived cells also express VDR, and thus it is currently hypothesized that 1,25(OH)2 vitamin D (1,25D) directly controls specific aspects of bone and mineral homeostasis. Several forms of vitamin D have been shown to induce specific and direct effects on different cells from bone and cartilage, such as chondrocytes, osteoblasts, osteocytes, osteoclasts and bone marrow stromal cells. Both catabolic and anabolic effects of vitamin D have been demonstrated in bone, mediated by different signal transduction mechanisms. In addition to the classic VDR mediated actions, non-classic and rapid effects of vitamin D have also been demonstrated in bone cells.
format Articulo
Revision
author Braziunas, Marisol Denise
Cortizo, Ana María
author_facet Braziunas, Marisol Denise
Cortizo, Ana María
author_sort Braziunas, Marisol Denise
title Vitamin D-VDR signaling in bone cells
title_short Vitamin D-VDR signaling in bone cells
title_full Vitamin D-VDR signaling in bone cells
title_fullStr Vitamin D-VDR signaling in bone cells
title_full_unstemmed Vitamin D-VDR signaling in bone cells
title_sort vitamin d-vdr signaling in bone cells
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/125640
https://pmr.safisiol.org.ar/archive/id/71
work_keys_str_mv AT braziunasmarisoldenise vitamindvdrsignalinginbonecells
AT cortizoanamaria vitamindvdrsignalinginbonecells
bdutipo_str Repositorios
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