Deleterious effects of inflammation on parturition and fetal development

Preterm birth is a major determinant of neonatal mortality and morbidity worldwide. One of the main causes of preterm parturition is maternal infection Dissemination of microorganisms from the vagina and cervix via the ascending route is the preponderant way of infection, although microorganisms may...

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Autores principales: Correa, Fernando, Schander, Julieta, Domínguez Rubio, Ana Paula, Franchi, Ana María
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2014
Materias:
Ciencias Médicas
Pregnancy
Preterm birth
Infection
Inflammation
Fetal damage
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125635
https://pmr.safisiol.org.ar/archive/id/64
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125635
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Pregnancy
Preterm birth
Infection
Inflammation
Fetal damage
spellingShingle Ciencias Médicas
Pregnancy
Preterm birth
Infection
Inflammation
Fetal damage
Correa, Fernando
Schander, Julieta
Domínguez Rubio, Ana Paula
Franchi, Ana María
Deleterious effects of inflammation on parturition and fetal development
topic_facet Ciencias Médicas
Pregnancy
Preterm birth
Infection
Inflammation
Fetal damage
description Preterm birth is a major determinant of neonatal mortality and morbidity worldwide. One of the main causes of preterm parturition is maternal infection Dissemination of microorganisms from the vagina and cervix via the ascending route is the preponderant way of infection, although microorganisms may also access the amniotic cavity and the fetus via other pathways. The pathophysiological processes that are set in motion during maternal infection lead to preterm labor and fetal damage with severe consequences both for the mother as well as the offspring. During inflammation associated to infection, a plethora of pro-inflammatory agents are produced in high levels. Thus, prostaglandins are released simultaneously with nitric oxide and their overproduction promotes uterine contractions contributing to embryonic and fetal expulsion. Oxygen and nitrogen reactive species and proinflammatory cytokines have been associated with preterm birth as well as fetal damage and they might contribute to the high mortality and morbidity associated with preterm labor. The study of these pathophysiological processes is necessary to develop better tocolytic agents. Therefore, it is essential to establish good animal models of infection-induced preterm labor that would mimic the human parturition biology.
format Articulo
Revision
author Correa, Fernando
Schander, Julieta
Domínguez Rubio, Ana Paula
Franchi, Ana María
author_facet Correa, Fernando
Schander, Julieta
Domínguez Rubio, Ana Paula
Franchi, Ana María
author_sort Correa, Fernando
title Deleterious effects of inflammation on parturition and fetal development
title_short Deleterious effects of inflammation on parturition and fetal development
title_full Deleterious effects of inflammation on parturition and fetal development
title_fullStr Deleterious effects of inflammation on parturition and fetal development
title_full_unstemmed Deleterious effects of inflammation on parturition and fetal development
title_sort deleterious effects of inflammation on parturition and fetal development
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/125635
https://pmr.safisiol.org.ar/archive/id/64
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