Hepatic and intestinal biotransformation and transport of xenobiotics during pregnancy and lactation

The liver is the main place for phase II metabolism and transport of xenobiotics mediated by Mrp2, leading to elimination of conjugated metabolites into bile. In the gastrointestinal tract, phase II enzymes and Mrp2 are preferentially localized in the proximal region of the small intestine, particul...

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Detalles Bibliográficos
Autores principales: Arana, Maite, Arias, Agostina, Villanueva, Silvina, Mottino, Aldo
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2014
Materias:
Bioquímica
Liver
Intestine
Phase II reactions
Mrp2
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125634
https://pmr.safisiol.org.ar/archive/id/62
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125634
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Liver
Intestine
Phase II reactions
Mrp2
spellingShingle Bioquímica
Liver
Intestine
Phase II reactions
Mrp2
Arana, Maite
Arias, Agostina
Villanueva, Silvina
Mottino, Aldo
Hepatic and intestinal biotransformation and transport of xenobiotics during pregnancy and lactation
topic_facet Bioquímica
Liver
Intestine
Phase II reactions
Mrp2
description The liver is the main place for phase II metabolism and transport of xenobiotics mediated by Mrp2, leading to elimination of conjugated metabolites into bile. In the gastrointestinal tract, phase II enzymes and Mrp2 are preferentially localized in the proximal region of the small intestine, particularly at the tip of the villus. In pregnant rats, conjugating enzymes (e.g. UGT and GST) and Mrp2-mediated transport of xenobiotics are decreased when compared to normal females, whereas these systems are preserved in small intestine, suggesting a complementary role for this tissue. After delivery, these same enzymes increase their expression and activity, being maximal during the last week of lactation. Mrp2 protein in liver also recovers and reaches the control level by the end of the lactation period. Post-partum rats exhibit a significant increase in development of the digestive tract in association with induction of phase II enzymes and Mrp2 expression and activity. Although the factors involved in regulation of protein expression may not be the same for conjugating enzymes and Mrp2 in the different experimental situations or tissues studied, their common localization and co-regulation provide evidence that they may work in cooperation. This is not surprising if we consider that most of the substrates for MRPs are the products that result from phase II reactions. Here, we provide a brief description of regulation of major phase II enzymes and Mrp2 during pregnancy and lactation, as particularly seen in the rat.
format Articulo
Revision
author Arana, Maite
Arias, Agostina
Villanueva, Silvina
Mottino, Aldo
author_facet Arana, Maite
Arias, Agostina
Villanueva, Silvina
Mottino, Aldo
author_sort Arana, Maite
title Hepatic and intestinal biotransformation and transport of xenobiotics during pregnancy and lactation
title_short Hepatic and intestinal biotransformation and transport of xenobiotics during pregnancy and lactation
title_full Hepatic and intestinal biotransformation and transport of xenobiotics during pregnancy and lactation
title_fullStr Hepatic and intestinal biotransformation and transport of xenobiotics during pregnancy and lactation
title_full_unstemmed Hepatic and intestinal biotransformation and transport of xenobiotics during pregnancy and lactation
title_sort hepatic and intestinal biotransformation and transport of xenobiotics during pregnancy and lactation
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/125634
https://pmr.safisiol.org.ar/archive/id/62
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AT ariasagostina hepaticandintestinalbiotransformationandtransportofxenobioticsduringpregnancyandlactation
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AT mottinoaldo hepaticandintestinalbiotransformationandtransportofxenobioticsduringpregnancyandlactation
bdutipo_str Repositorios
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