The role of the neuregulin-1/erbb signaling pathway in cardiac morphogenesis and remodeling

Neuregulin-1 (NRG1) signaling through tyrosine kinase receptors erbB2 and erbB4 was revealed essential for cardiac development as mouse mutated in the Nrg1 or either cognate receptors Erbb2 or Erbb4 genes lack the formation of trabeculae at the ventricular wall. Indeed, the injection of the NRG1 ac...

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Detalles Bibliográficos
Autores principales: Vasti, Cecilia, Hertig, Cecilia
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2014
Materias:
Biología
Neuregulin-1
Remodeling
erbB
Cardiac morphogenesis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125631
https://pmr.safisiol.org.ar/archive/id/61
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125631
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Neuregulin-1
Remodeling
erbB
Cardiac morphogenesis
spellingShingle Biología
Neuregulin-1
Remodeling
erbB
Cardiac morphogenesis
Vasti, Cecilia
Hertig, Cecilia
The role of the neuregulin-1/erbb signaling pathway in cardiac morphogenesis and remodeling
topic_facet Biología
Neuregulin-1
Remodeling
erbB
Cardiac morphogenesis
description Neuregulin-1 (NRG1) signaling through tyrosine kinase receptors erbB2 and erbB4 was revealed essential for cardiac development as mouse mutated in the Nrg1 or either cognate receptors Erbb2 or Erbb4 genes lack the formation of trabeculae at the ventricular wall. Indeed, the injection of the NRG1 active peptide in developing embryos induced trabeculation of the ventricular free wall. The components of the NRG1 pathway have been identified and the cardiac activities are being progressively characterized. An acquired form of dilated cardiomyopathy was evidenced in a subpopulation of breast tumor patients undergoing a combined treatment with antibodies against erbB2 and chemotherapy. In this regard, the cardiomyocyte-specific gene deletion of either erbb2 or erbb4 leads to ventricular dilation in adult mice, providing an experimental model system to examine the NRG1-mediated activities. We reviewed the evidence on the growing field of research for NRG1 signaling in both cardiac morphogenesis and in the postnatal myocardial remodeling.
format Articulo
Revision
author Vasti, Cecilia
Hertig, Cecilia
author_facet Vasti, Cecilia
Hertig, Cecilia
author_sort Vasti, Cecilia
title The role of the neuregulin-1/erbb signaling pathway in cardiac morphogenesis and remodeling
title_short The role of the neuregulin-1/erbb signaling pathway in cardiac morphogenesis and remodeling
title_full The role of the neuregulin-1/erbb signaling pathway in cardiac morphogenesis and remodeling
title_fullStr The role of the neuregulin-1/erbb signaling pathway in cardiac morphogenesis and remodeling
title_full_unstemmed The role of the neuregulin-1/erbb signaling pathway in cardiac morphogenesis and remodeling
title_sort role of the neuregulin-1/erbb signaling pathway in cardiac morphogenesis and remodeling
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/125631
https://pmr.safisiol.org.ar/archive/id/61
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