The Dietary Lipid Content Affects the Tissue Gene Expression of Muscle Growth Biomarkers and the GH/IGF System of Pejerrey (<i>Odontesthes bonariensis</i>) Juveniles

Gene expression of growth hormone receptors (GHRs), insulin-like growth factors (IGFs), myostatin (MSTN) and myogenin (MyoG) was analyzed in juveniles pejerrey fed with graded levels of lipids (L): 6% (L6), 10% (L10), 25% (L25). After 14 weeks, no changes were found in liver GHR-I GHR-II and IGF-II...

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Autores principales: Gómez Requeni, Pedro, Kraemer, Mauricio Néstor, Canosa, Luis
Formato: Articulo
Lenguaje:Inglés
Publicado: 2019
Materias:
Ciencias Médicas
dietary lipids
growth biomarkers
somatotropic axis
neotropical teleost
animal nutrition
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125608
https://www.mdpi.com/2410-3888/4/3/37
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125608
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
dietary lipids
growth biomarkers
somatotropic axis
neotropical teleost
animal nutrition
spellingShingle Ciencias Médicas
dietary lipids
growth biomarkers
somatotropic axis
neotropical teleost
animal nutrition
Gómez Requeni, Pedro
Kraemer, Mauricio Néstor
Canosa, Luis
The Dietary Lipid Content Affects the Tissue Gene Expression of Muscle Growth Biomarkers and the GH/IGF System of Pejerrey (<i>Odontesthes bonariensis</i>) Juveniles
topic_facet Ciencias Médicas
dietary lipids
growth biomarkers
somatotropic axis
neotropical teleost
animal nutrition
description Gene expression of growth hormone receptors (GHRs), insulin-like growth factors (IGFs), myostatin (MSTN) and myogenin (MyoG) was analyzed in juveniles pejerrey fed with graded levels of lipids (L): 6% (L6), 10% (L10), 25% (L25). After 14 weeks, no changes were found in liver GHR-I GHR-II and IGF-II mRNA levels whereas IGF-I decreased in L10 and L25. Muscle GHR-I gene expression increased in L25 whereas GHR-II, IGF-II and MyoG were higher in L6. IGF-I and MSTN expression was not affected by the different diets. Adipose IGF-I mRNA levels decreased in L10. Correlations between body weight and members of GH/IGF system in liver and skeletal muscle were found only in L10 group. Correlations found in L10 group between both liver and skeletal muscle GHR-I and IGF-I were lost in either L6 or L25 groups. Thus, fish fed with apparently unbalanced dietary lipid contents (6% and 25%) exhibit a compensatory regulation of systemic and local components of the GH/IGF axis. Furthermore, the marked inhibition of muscle MyoG gene expression in L25 might limit excessive lipid deposition and fish growth. Our data suggest that a dietary lipid contents of 10% would promote a particular adjustment of the endocrine and autocrine/paracrine GH/IGF system, stimulating body growth and perhaps muscle hyperplasia. On the other hand, a higher dietary lipid content would uncouple the GH/IGF system, reducing hepatic IGF-I, while slightly increasing hepatic GHR-I, probably to prompt lipolysis.
format Articulo
Articulo
author Gómez Requeni, Pedro
Kraemer, Mauricio Néstor
Canosa, Luis
author_facet Gómez Requeni, Pedro
Kraemer, Mauricio Néstor
Canosa, Luis
author_sort Gómez Requeni, Pedro
title The Dietary Lipid Content Affects the Tissue Gene Expression of Muscle Growth Biomarkers and the GH/IGF System of Pejerrey (<i>Odontesthes bonariensis</i>) Juveniles
title_short The Dietary Lipid Content Affects the Tissue Gene Expression of Muscle Growth Biomarkers and the GH/IGF System of Pejerrey (<i>Odontesthes bonariensis</i>) Juveniles
title_full The Dietary Lipid Content Affects the Tissue Gene Expression of Muscle Growth Biomarkers and the GH/IGF System of Pejerrey (<i>Odontesthes bonariensis</i>) Juveniles
title_fullStr The Dietary Lipid Content Affects the Tissue Gene Expression of Muscle Growth Biomarkers and the GH/IGF System of Pejerrey (<i>Odontesthes bonariensis</i>) Juveniles
title_full_unstemmed The Dietary Lipid Content Affects the Tissue Gene Expression of Muscle Growth Biomarkers and the GH/IGF System of Pejerrey (<i>Odontesthes bonariensis</i>) Juveniles
title_sort dietary lipid content affects the tissue gene expression of muscle growth biomarkers and the gh/igf system of pejerrey (<i>odontesthes bonariensis</i>) juveniles
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/125608
https://www.mdpi.com/2410-3888/4/3/37
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