A non-coding RNA network involved in KSHV tumorigenesis

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Regulatory pathways involving non-coding RNAs (ncRNAs) such as microRNAs (miRNAs) and long non-coding RNAs (lncRNA) have gained great relevance due to their role in the control of gene expression modulation. Using RNA sequencing of KSHV Bac36 transfected mouse endothelial cells (mECK36) and tumors,...

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Autores principales: Naipauer, Julian, García Solá, Martín E., Salyakina, Daria, Rosario, Santas, Williams, Sion, Coso, Omar, Abba, Martín Carlos, Mesri, Enrique A., Lacunza, Ezequiel
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Médicas
lncRNAs
miRNAs
KSHV
Network pathways
Druggable targets.
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125572
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125572
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
lncRNAs
miRNAs
KSHV
Network pathways
Druggable targets.
spellingShingle Ciencias Médicas
lncRNAs
miRNAs
KSHV
Network pathways
Druggable targets.
Naipauer, Julian
García Solá, Martín E.
Salyakina, Daria
Rosario, Santas
Williams, Sion
Coso, Omar
Abba, Martín Carlos
Mesri, Enrique A.
Lacunza, Ezequiel
A non-coding RNA network involved in KSHV tumorigenesis
topic_facet Ciencias Médicas
lncRNAs
miRNAs
KSHV
Network pathways
Druggable targets.
description Regulatory pathways involving non-coding RNAs (ncRNAs) such as microRNAs (miRNAs) and long non-coding RNAs (lncRNA) have gained great relevance due to their role in the control of gene expression modulation. Using RNA sequencing of KSHV Bac36 transfected mouse endothelial cells (mECK36) and tumors, we have analyzed the host and viral transcriptome to uncover the role lncRNA-miRNA-mRNA driven networks in KSHV tumorigenesis. The integration of the differentially expressed ncRNAs, with an exhaustive computational analysis of their experimentally supported targets, led us to dissect complex networks integrated by the cancer-related lncRNAs Malat, Neat1, H19, Meg3 and their associated miRNA-target pairs. These networks would modulate pathways related to KSHV pathogenesis, such as viral carcinogenesis, p53 signaling, RNA surveillance, and Cell cycle control. Finally, the ncRNA-mRNA analysis allowed us to develop signatures that can be used to an appropriate identification of druggable gene or networks defining relevant AIDS-KS therapeutic targets.
format Articulo
Preprint
author Naipauer, Julian
García Solá, Martín E.
Salyakina, Daria
Rosario, Santas
Williams, Sion
Coso, Omar
Abba, Martín Carlos
Mesri, Enrique A.
Lacunza, Ezequiel
author_facet Naipauer, Julian
García Solá, Martín E.
Salyakina, Daria
Rosario, Santas
Williams, Sion
Coso, Omar
Abba, Martín Carlos
Mesri, Enrique A.
Lacunza, Ezequiel
author_sort Naipauer, Julian
title A non-coding RNA network involved in KSHV tumorigenesis
title_short A non-coding RNA network involved in KSHV tumorigenesis
title_full A non-coding RNA network involved in KSHV tumorigenesis
title_fullStr A non-coding RNA network involved in KSHV tumorigenesis
title_full_unstemmed A non-coding RNA network involved in KSHV tumorigenesis
title_sort non-coding rna network involved in kshv tumorigenesis
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/125572
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