Modeling Cardiomyopathies in a Dish: State-of-the-Art and Novel Perspectives on hiPSC-Derived Cardiomyocytes Maturation

The stem cell technology and the induced pluripotent stem cells (iPSCs) production represent an excellent alternative tool to study cardiomyopathies, which overcome the limitations associated with primary cardiomyocytes (CMs) access and manipulation. CMs from human iPSCs (hiPSC–CMs) are genetically...

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Detalles Bibliográficos
Autores principales: Lodola, Francesco, De Giusti, Verónica Celeste, Maniezzi, Claudia, Martone, Daniele, Stadiotti, Ilaria, Sommariva, Elena, Maione, Angela
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Médicas
hiPSC-CMs
Cardiomyopathies
Cardiovascular disease modeling
Patient-specific medicine
Stem cell maturation
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125449
https://www.mdpi.com/2079-7737/10/8/730
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125449
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
hiPSC-CMs
Cardiomyopathies
Cardiovascular disease modeling
Patient-specific medicine
Stem cell maturation
spellingShingle Ciencias Médicas
hiPSC-CMs
Cardiomyopathies
Cardiovascular disease modeling
Patient-specific medicine
Stem cell maturation
Lodola, Francesco
De Giusti, Verónica Celeste
Maniezzi, Claudia
Martone, Daniele
Stadiotti, Ilaria
Sommariva, Elena
Maione, Angela
Modeling Cardiomyopathies in a Dish: State-of-the-Art and Novel Perspectives on hiPSC-Derived Cardiomyocytes Maturation
topic_facet Ciencias Médicas
hiPSC-CMs
Cardiomyopathies
Cardiovascular disease modeling
Patient-specific medicine
Stem cell maturation
description The stem cell technology and the induced pluripotent stem cells (iPSCs) production represent an excellent alternative tool to study cardiomyopathies, which overcome the limitations associated with primary cardiomyocytes (CMs) access and manipulation. CMs from human iPSCs (hiPSC–CMs) are genetically identical to patient primary cells of origin, with the main electrophysiological and mechanical features of CMs. The key issue to be solved is to achieve a degree of structural and functional maturity typical of adult CMs. In this perspective, we will focus on the main differences between fetal-like hiPSC-CMs and adult CMs. A viewpoint is given on the different approaches used to improve hiPSC-CMs maturity, spanning from long-term culture to complex engineered heart tissue. Further, we outline limitations and future developments needed in cardiomyopathy disease modeling.
format Articulo
Articulo
author Lodola, Francesco
De Giusti, Verónica Celeste
Maniezzi, Claudia
Martone, Daniele
Stadiotti, Ilaria
Sommariva, Elena
Maione, Angela
author_facet Lodola, Francesco
De Giusti, Verónica Celeste
Maniezzi, Claudia
Martone, Daniele
Stadiotti, Ilaria
Sommariva, Elena
Maione, Angela
author_sort Lodola, Francesco
title Modeling Cardiomyopathies in a Dish: State-of-the-Art and Novel Perspectives on hiPSC-Derived Cardiomyocytes Maturation
title_short Modeling Cardiomyopathies in a Dish: State-of-the-Art and Novel Perspectives on hiPSC-Derived Cardiomyocytes Maturation
title_full Modeling Cardiomyopathies in a Dish: State-of-the-Art and Novel Perspectives on hiPSC-Derived Cardiomyocytes Maturation
title_fullStr Modeling Cardiomyopathies in a Dish: State-of-the-Art and Novel Perspectives on hiPSC-Derived Cardiomyocytes Maturation
title_full_unstemmed Modeling Cardiomyopathies in a Dish: State-of-the-Art and Novel Perspectives on hiPSC-Derived Cardiomyocytes Maturation
title_sort modeling cardiomyopathies in a dish: state-of-the-art and novel perspectives on hipsc-derived cardiomyocytes maturation
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/125449
https://www.mdpi.com/2079-7737/10/8/730
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