Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease

The small intestine has a high rate of cell turnover under homeostatic conditions, and this increases further in response to infection or damage. Epithelial cells mostly die by apoptosis, but recent studies indicate that this may also involve pro-inflammatory pathways of programmed cell death, such...

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Detalles Bibliográficos
Autores principales: Pérez, Federico, Ruera, Carolina Naymé, Miculán, Emanuel Gonzalo, Carasi, Paula, Chirdo, Fernando Gabriel
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Biología
Celiac disease
Alarmins
Programmed cell death
Inflammation
Small intestine
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125443
https://www.mdpi.com/1422-0067/22/14/7426
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125443
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Celiac disease
Alarmins
Programmed cell death
Inflammation
Small intestine
spellingShingle Biología
Celiac disease
Alarmins
Programmed cell death
Inflammation
Small intestine
Pérez, Federico
Ruera, Carolina Naymé
Miculán, Emanuel Gonzalo
Carasi, Paula
Chirdo, Fernando Gabriel
Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
topic_facet Biología
Celiac disease
Alarmins
Programmed cell death
Inflammation
Small intestine
description The small intestine has a high rate of cell turnover under homeostatic conditions, and this increases further in response to infection or damage. Epithelial cells mostly die by apoptosis, but recent studies indicate that this may also involve pro-inflammatory pathways of programmed cell death, such as pyroptosis and necroptosis. Celiac disease (CD), the most prevalent immune-based enteropathy, is caused by loss of oral tolerance to peptides derived from wheat, rye, and barley in genetically predisposed individuals. Although cytotoxic cells and gluten-specific CD4+ Th1 cells are the central players in the pathology, inflammatory pathways induced by cell death may participate in driving and sustaining the disease through the release of alarmins. In this review, we summarize the recent literature addressing the role of programmed cell death pathways in the small intestine, describing how these mechanisms may contribute to CD and discussing their potential implications.
format Articulo
Articulo
author Pérez, Federico
Ruera, Carolina Naymé
Miculán, Emanuel Gonzalo
Carasi, Paula
Chirdo, Fernando Gabriel
author_facet Pérez, Federico
Ruera, Carolina Naymé
Miculán, Emanuel Gonzalo
Carasi, Paula
Chirdo, Fernando Gabriel
author_sort Pérez, Federico
title Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
title_short Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
title_full Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
title_fullStr Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
title_full_unstemmed Programmed Cell Death in the Small Intestine: Implications for the Pathogenesis of Celiac Disease
title_sort programmed cell death in the small intestine: implications for the pathogenesis of celiac disease
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/125443
https://www.mdpi.com/1422-0067/22/14/7426
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