Heat stress induces ferroptosis in a photosynthetic prokaryote

Ferroptosis is an oxidative iron-dependent form of cell death recently described in eukaryotic organisms like animals, plants and parasites. Here we report that a similar process takes place in the cyanobacterium Synechocystis sp. PCC 6803 in response to heat stress. After a heat shock, Synechocysti...

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Detalles Bibliográficos
Autores principales: Aguilera, Anabella, Berdun, Federico, Bartoli, Carlos Guillermo, Steelheart Molina, María Charlotte, Alegre, Matías Leonel, Salerno, Graciela L., Pagnussat, Gabriela Carolina, Martin, María Victori
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2019
Materias:
Ciencias Agrarias
Ciencias Naturales
ferroptosis
photosynthetic prokaryote
Synechocystis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125291
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125291
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Agrarias
Ciencias Naturales
ferroptosis
photosynthetic prokaryote
Synechocystis
spellingShingle Ciencias Agrarias
Ciencias Naturales
ferroptosis
photosynthetic prokaryote
Synechocystis
Aguilera, Anabella
Berdun, Federico
Bartoli, Carlos Guillermo
Steelheart Molina, María Charlotte
Alegre, Matías Leonel
Salerno, Graciela L.
Pagnussat, Gabriela Carolina
Martin, María Victori
Heat stress induces ferroptosis in a photosynthetic prokaryote
topic_facet Ciencias Agrarias
Ciencias Naturales
ferroptosis
photosynthetic prokaryote
Synechocystis
description Ferroptosis is an oxidative iron-dependent form of cell death recently described in eukaryotic organisms like animals, plants and parasites. Here we report that a similar process takes place in the cyanobacterium Synechocystis sp. PCC 6803 in response to heat stress. After a heat shock, Synechocystis cells undergo a cell death pathway that can be suppressed by canonical ferroptosis inhibitors or by external addition of calcium, glutathione or ascorbic acid. Moreover, as described for eukaryotic cells ferroptosis, this pathway is characterized by an early depletion of antioxidants, and by lipid peroxidation. As in general prokaryotes membranes contain poorly oxidizable saturated or monounsaturated lipid molecules, it was thought that they were not susceptible to ferroptosis. Interestingly, cyanobacteria contain thylakoid membranes that are enriched in polyunsaturated-fatty-acid-containing phospholipids, which might explain their sensitivity to ferroptosis. These results indicate that all of the hallmarks described for eukaryotic ferroptosis are conserved in photosynthetic prokaryotes and suggest that ferroptosis might be an ancient cell death program.
format Articulo
Preprint
author Aguilera, Anabella
Berdun, Federico
Bartoli, Carlos Guillermo
Steelheart Molina, María Charlotte
Alegre, Matías Leonel
Salerno, Graciela L.
Pagnussat, Gabriela Carolina
Martin, María Victori
author_facet Aguilera, Anabella
Berdun, Federico
Bartoli, Carlos Guillermo
Steelheart Molina, María Charlotte
Alegre, Matías Leonel
Salerno, Graciela L.
Pagnussat, Gabriela Carolina
Martin, María Victori
author_sort Aguilera, Anabella
title Heat stress induces ferroptosis in a photosynthetic prokaryote
title_short Heat stress induces ferroptosis in a photosynthetic prokaryote
title_full Heat stress induces ferroptosis in a photosynthetic prokaryote
title_fullStr Heat stress induces ferroptosis in a photosynthetic prokaryote
title_full_unstemmed Heat stress induces ferroptosis in a photosynthetic prokaryote
title_sort heat stress induces ferroptosis in a photosynthetic prokaryote
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/125291
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