Enantiomeric separations by capillary electrophoresis: Theoretical method to determine optimum chiral selector concentration

A method to optimize the ligand concentration [S] in the background electrolyte of capillary electrophoresis separations is presented. It is based on the use of a model which predicts apparent electrophoretic mobilities as a function of ligand concentration (expressed as p[S] = −log[S]). This model...

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Detalles Bibliográficos
Autores principales:	Lancioni, Carlina, Keunchkarian, Sonia, Castells, Cecilia Beatriz Marta, Gagliardi, Leonardo Gabriel
Formato:	Articulo Preprint
Lenguaje:	Inglés
Publicado:	2018
Materias:	Química Capillary electrophoresis Cyclodextrin Chiral separation Separation optimization Multicriterion optimization function
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/125104
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-125104
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Química Capillary electrophoresis Cyclodextrin Chiral separation Separation optimization Multicriterion optimization function
spellingShingle	Química Capillary electrophoresis Cyclodextrin Chiral separation Separation optimization Multicriterion optimization function Lancioni, Carlina Keunchkarian, Sonia Castells, Cecilia Beatriz Marta Gagliardi, Leonardo Gabriel Enantiomeric separations by capillary electrophoresis: Theoretical method to determine optimum chiral selector concentration
topic_facet	Química Capillary electrophoresis Cyclodextrin Chiral separation Separation optimization Multicriterion optimization function
description	A method to optimize the ligand concentration [S] in the background electrolyte of capillary electrophoresis separations is presented. It is based on the use of a model which predicts apparent electrophoretic mobilities as a function of ligand concentration (expressed as p[S] = −log[S]). This model is employed to compose the expression of a recently proposed criterion to qualify separations in electrophoresis. Two strategies to find the optimum p[S], leading to the best separation of all compounds, are explained: 1.- a graphical method using a windows map depicting the single separation criteria between all possible combination of compounds by pairs, and 2.- an analytical method where an extended multicriterion optimization function is composed and optimum p[S] is found by mathematical maximization. The procedure is applied to a hard-to-separate model system: enantiomeric separations of racemic mixtures. 2-Hydroxypropyl-β-cyclodextrin was chosen as a model ligand, and four pharmaceutical drugs as model analytes. In order to demonstrate the performance of the procedure, results of electrophoretic separations obtained at p[S] found as optimum are compared with separations obtained at p[S] values slightly higher and lower than the optimum.
format	Articulo Preprint
author	Lancioni, Carlina Keunchkarian, Sonia Castells, Cecilia Beatriz Marta Gagliardi, Leonardo Gabriel
author_facet	Lancioni, Carlina Keunchkarian, Sonia Castells, Cecilia Beatriz Marta Gagliardi, Leonardo Gabriel
author_sort	Lancioni, Carlina
title	Enantiomeric separations by capillary electrophoresis: Theoretical method to determine optimum chiral selector concentration
title_short	Enantiomeric separations by capillary electrophoresis: Theoretical method to determine optimum chiral selector concentration
title_full	Enantiomeric separations by capillary electrophoresis: Theoretical method to determine optimum chiral selector concentration
title_fullStr	Enantiomeric separations by capillary electrophoresis: Theoretical method to determine optimum chiral selector concentration
title_full_unstemmed	Enantiomeric separations by capillary electrophoresis: Theoretical method to determine optimum chiral selector concentration
title_sort	enantiomeric separations by capillary electrophoresis: theoretical method to determine optimum chiral selector concentration
publishDate	2018
url	http://sedici.unlp.edu.ar/handle/10915/125104
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bdutipo_str	Repositorios
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Enantiomeric separations by capillary electrophoresis: Theoretical method to determine optimum chiral selector concentration

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