Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction

Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not cl...

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Autores principales: Barbeito Andrés, Jimena, Castro Fonseca, Emily, Qiu, Lily R., Bernal, Valeria, Lent, Roberto, Henkelman, Mark, Lukowiak, Ken, Gleiser, Pablo M., Hallgrimsson, Benedikt, González, Paula Natalia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2019
Materias:
Ciencias Naturales
Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125046
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125046
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Naturales
Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator
spellingShingle Ciencias Naturales
Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator
Barbeito Andrés, Jimena
Castro Fonseca, Emily
Qiu, Lily R.
Bernal, Valeria
Lent, Roberto
Henkelman, Mark
Lukowiak, Ken
Gleiser, Pablo M.
Hallgrimsson, Benedikt
González, Paula Natalia
Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
topic_facet Ciencias Naturales
Brain sparing
Brain cortex
Cerebellum
Magnetic resonance imaging
Isotropic fractionator
description Nutrition is one of the most influential environmental factors affecting the development of different tissues and organs. It is suggested that under nutrient restriction the growth of the brain is spared as a result of the differential allocation of resources from other organs. However, it is not clear whether this sparing occurs brain-wide. Here, we analyzed morphological changes and cell composition in different regions of the offspring mouse brain after maternal exposure to nutrient restriction during pregnancy and lactation. Using high-resolution magnetic resonance imaging, we found that brain regions were differentially sensitive to maternal protein restriction and exhibited particular patterns of volume reduction. The cerebellum was reduced in absolute and relative volume, while cortex volume was relatively preserved. Alterations in cell composition (examined by the isotropic fractionator method) and organization of white matter (measured by diffusor tensor images) were also region specific. These changes were not related to the metabolic rate of the regions and were only partially explained by their specific growth trajectories. This study is a first step towards understanding the mechanisms of regional brain sparing at microstructural and macrostructural levels resulting from undernutrition.
format Articulo
Articulo
author Barbeito Andrés, Jimena
Castro Fonseca, Emily
Qiu, Lily R.
Bernal, Valeria
Lent, Roberto
Henkelman, Mark
Lukowiak, Ken
Gleiser, Pablo M.
Hallgrimsson, Benedikt
González, Paula Natalia
author_facet Barbeito Andrés, Jimena
Castro Fonseca, Emily
Qiu, Lily R.
Bernal, Valeria
Lent, Roberto
Henkelman, Mark
Lukowiak, Ken
Gleiser, Pablo M.
Hallgrimsson, Benedikt
González, Paula Natalia
author_sort Barbeito Andrés, Jimena
title Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
title_short Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
title_full Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
title_fullStr Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
title_full_unstemmed Region-specific changes in <i>Mus musculus</i> brain size and cell composition under chronic nutrient restriction
title_sort region-specific changes in <i>mus musculus</i> brain size and cell composition under chronic nutrient restriction
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/125046
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