Dataset of the construction and characterization of stable biological nanoparticles

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We suggest that the structural flexibility is key for certain proteins in order to fulfill functions that are required to interact with biological membranes, and that intra-chain chemical crosslinking may result in a different arrangement of protein with lipids. As interaction with biological membra...

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Autores principales: Gisonno, Romina Antonela, Tricerri, María Alejandra, González, Marina Cecilia, Garda, Horacio Alberto, Ramella, Nahuel Alberto, Díaz Ludovico, Ivo
Formato: Articulo Preprint
Lenguaje:Español
Publicado: 2020
Materias:
Ciencias Médicas
Apolipoprotein A-I
BS3 Crosslinker
Lipid-Binding
Gradient gel electrophoresis
Nanoparticles
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/125022
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-125022
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Médicas
Apolipoprotein A-I
BS3 Crosslinker
Lipid-Binding
Gradient gel electrophoresis
Nanoparticles
spellingShingle Ciencias Médicas
Apolipoprotein A-I
BS3 Crosslinker
Lipid-Binding
Gradient gel electrophoresis
Nanoparticles
Gisonno, Romina Antonela
Tricerri, María Alejandra
González, Marina Cecilia
Garda, Horacio Alberto
Ramella, Nahuel Alberto
Díaz Ludovico, Ivo
Dataset of the construction and characterization of stable biological nanoparticles
topic_facet Ciencias Médicas
Apolipoprotein A-I
BS3 Crosslinker
Lipid-Binding
Gradient gel electrophoresis
Nanoparticles
description We suggest that the structural flexibility is key for certain proteins in order to fulfill functions that are required to interact with biological membranes, and that intra-chain chemical crosslinking may result in a different arrangement of protein with lipids. As interaction with biological membranes and lipids is a function attributed to many proteins in circulation, we intended to characterize an experimental design that helps in the study of many biological protein structures and their function. But in addition, by introducing intra-chain crosslinking, we obtained discoidal nano platforms that are stable under different conditions of temperate and time incubation. These platforms might be an excellent model to employ as biological carriers of intrinsic or external molecules. Thus, data shown here clearly strengthen the usefulness of an easy, accessible and inexpensive tool not only to study protein-lipid interactions, but to be used in different biological fields that require the transport of organic compounds.
format Articulo
Preprint
author Gisonno, Romina Antonela
Tricerri, María Alejandra
González, Marina Cecilia
Garda, Horacio Alberto
Ramella, Nahuel Alberto
Díaz Ludovico, Ivo
author_facet Gisonno, Romina Antonela
Tricerri, María Alejandra
González, Marina Cecilia
Garda, Horacio Alberto
Ramella, Nahuel Alberto
Díaz Ludovico, Ivo
author_sort Gisonno, Romina Antonela
title Dataset of the construction and characterization of stable biological nanoparticles
title_short Dataset of the construction and characterization of stable biological nanoparticles
title_full Dataset of the construction and characterization of stable biological nanoparticles
title_fullStr Dataset of the construction and characterization of stable biological nanoparticles
title_full_unstemmed Dataset of the construction and characterization of stable biological nanoparticles
title_sort dataset of the construction and characterization of stable biological nanoparticles
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/125022
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