Phagocyte Escape of <i>Leptospira</i>: The Role of TLRs and NLRs

The spirochetal bacteria <i>Leptospira</i> spp. are causative agents of leptospirosis, a globally neglected and reemerging zoonotic disease. Infection with these pathogens may lead to an acute and potentially fatal disease but also to chronic asymptomatic renal colonization. Both forms o...

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Detalles Bibliográficos
Autores principales: Santecchia, Ignacio, Ferrer, María Florencia, Vieira, Monica L., Gómez, Ricardo Martín, Werts, Catherine
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Ciencias Exactas
Biología
leptospires
phagocytes
macrophages
neutrophils
platelets
TLR—toll-like receptor
NLR (NOD-like receptor)
Zoonosis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124984
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-124984
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Biología
leptospires
phagocytes
macrophages
neutrophils
platelets
TLR—toll-like receptor
NLR (NOD-like receptor)
Zoonosis
spellingShingle Ciencias Exactas
Biología
leptospires
phagocytes
macrophages
neutrophils
platelets
TLR—toll-like receptor
NLR (NOD-like receptor)
Zoonosis
Santecchia, Ignacio
Ferrer, María Florencia
Vieira, Monica L.
Gómez, Ricardo Martín
Werts, Catherine
Phagocyte Escape of <i>Leptospira</i>: The Role of TLRs and NLRs
topic_facet Ciencias Exactas
Biología
leptospires
phagocytes
macrophages
neutrophils
platelets
TLR—toll-like receptor
NLR (NOD-like receptor)
Zoonosis
description The spirochetal bacteria <i>Leptospira</i> spp. are causative agents of leptospirosis, a globally neglected and reemerging zoonotic disease. Infection with these pathogens may lead to an acute and potentially fatal disease but also to chronic asymptomatic renal colonization. Both forms of disease demonstrate the ability of leptospires to evade the immune response of their hosts. In this review, we aim first to recapitulate the knowledge and explore the controversial data about the opsonization, recognition, intracellular survival, and killing of leptospires by scavenger cells, including platelets, neutrophils, macrophages, and dendritic cells. Second, we will summarize the known specificities of the recognition or escape of leptospire components (the so-called microbial-associated molecular patterns; MAMPs) by the pattern recognition receptors (PRRs) of the Toll-like and NOD-like families. These PRRs are expressed by phagocytes, and their stimulation by MAMPs triggers pro-inflammatory cytokine and chemokine production and bactericidal responses, such as antimicrobial peptide secretion and reactive oxygen species production. Finally, we will highlight recent studies suggesting that boosting or restoring phagocytic functions by treatments using agonists of the Toll-like or NOD receptors represents a novel prophylactic strategy and describe other potential therapeutic or vaccine strategies to combat leptospirosis.
format Articulo
Articulo
author Santecchia, Ignacio
Ferrer, María Florencia
Vieira, Monica L.
Gómez, Ricardo Martín
Werts, Catherine
author_facet Santecchia, Ignacio
Ferrer, María Florencia
Vieira, Monica L.
Gómez, Ricardo Martín
Werts, Catherine
author_sort Santecchia, Ignacio
title Phagocyte Escape of <i>Leptospira</i>: The Role of TLRs and NLRs
title_short Phagocyte Escape of <i>Leptospira</i>: The Role of TLRs and NLRs
title_full Phagocyte Escape of <i>Leptospira</i>: The Role of TLRs and NLRs
title_fullStr Phagocyte Escape of <i>Leptospira</i>: The Role of TLRs and NLRs
title_full_unstemmed Phagocyte Escape of <i>Leptospira</i>: The Role of TLRs and NLRs
title_sort phagocyte escape of <i>leptospira</i>: the role of tlrs and nlrs
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/124984
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