Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans
Current evidence reveals that cardiac mineralocorticoid receptor (MR) activation following myocardial stretch plays an important physiological role in adapting developed force to sudden changes in hemodynamic conditions. Its underlying mechanism involves a previously unknown nongenomic effect of the...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/124900 |
| Aporte de: |
| id |
I19-R120-10915-124900 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Medicina aldosterone mineralocorticoid receptor (MR) myocardial stretch heart failure NHE1 oxidative stress |
| spellingShingle |
Medicina aldosterone mineralocorticoid receptor (MR) myocardial stretch heart failure NHE1 oxidative stress Ennis, Irene Lucía Pérez, Néstor Gustavo Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans |
| topic_facet |
Medicina aldosterone mineralocorticoid receptor (MR) myocardial stretch heart failure NHE1 oxidative stress |
| description |
Current evidence reveals that cardiac mineralocorticoid receptor (MR) activation following myocardial stretch plays an important physiological role in adapting developed force to sudden changes in hemodynamic conditions. Its underlying mechanism involves a previously unknown nongenomic effect of the MR that triggers redox-mediated Na⁺/H⁺ exchanger (NHE1) activation, intracellular Na⁺ accumulation, and a consequent increase in Ca²⁺ transient amplitude through reverse Na⁺/Ca²⁺ exchange. However, clinical evidence assigns a detrimental role to MR activation in the pathogenesis of severe cardiac diseases such as congestive heart failure. This mini review is meant to present and briefly discuss some recent discoveries about locally triggered cardiac MR signals with the objective of shedding some light on its physiological but potentially pathological consequences in the heart. |
| format |
Articulo Articulo |
| author |
Ennis, Irene Lucía Pérez, Néstor Gustavo |
| author_facet |
Ennis, Irene Lucía Pérez, Néstor Gustavo |
| author_sort |
Ennis, Irene Lucía |
| title |
Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans |
| title_short |
Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans |
| title_full |
Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans |
| title_fullStr |
Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans |
| title_full_unstemmed |
Cardiac Mineralocorticoid Receptor and the Na⁺/H⁺ Exchanger: Spilling the Beans |
| title_sort |
cardiac mineralocorticoid receptor and the na⁺/h⁺ exchanger: spilling the beans |
| publishDate |
2021 |
| url |
http://sedici.unlp.edu.ar/handle/10915/124900 |
| work_keys_str_mv |
AT ennisirenelucia cardiacmineralocorticoidreceptorandthenahexchangerspillingthebeans AT pereznestorgustavo cardiacmineralocorticoidreceptorandthenahexchangerspillingthebeans |
| bdutipo_str |
Repositorios |
| _version_ |
1764820451276619781 |