Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women
Objective: Angiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variabl...
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| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2021
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/124865 |
| Aporte de: |
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I19-R120-10915-124865 |
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dspace |
| institution |
Universidad Nacional de La Plata |
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I-19 |
| repository_str |
R-120 |
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SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas ANGPTL3 Pregnancy Preeclampsia Insulin resistance ANGPTL |
| spellingShingle |
Ciencias Médicas ANGPTL3 Pregnancy Preeclampsia Insulin resistance ANGPTL Garcés, María Fernanda Rodriguez Navarro, Haiver Antonio Buell Acosta, Julieth Daniela Burgos Cardenas, Alvaro Javier Franco Vega, Roberto Maldonado Acosta, Luis Miguel Eslava Schmalbach, Javier Parada Baños, Arturo José Castro Pinzon, Andres Sanchez, Elizabeth Ángel Müller, Edith Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Ruiz Parra, Ariel Iván Caminos, Jorge E. Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women |
| topic_facet |
Ciencias Médicas ANGPTL3 Pregnancy Preeclampsia Insulin resistance ANGPTL |
| description |
Objective: Angiopoietin-like protein 3(ANGPTL3) is an important regulator of lipoprotein metabolism in the fed state by inhibiting the enzyme lipoprotein lipase in oxidative tissues. However, the possible role of ANGPTL3 throughout gestation and its relationship with hormonal and biochemical variables are still unknown. The aim of this study was to determinate serum ANGPTL3 level in healthy non-pregnant women, during healthy and preeclamptic pregnancy and postpartum. Methods: Serum ANGPTL3 was analyzed by enzyme-linked immunosorbent assay (ELISA), in a prospective cohort of healthy pregnant women (n = 52) and women with mild preeclampsia (n = 21), and women at three months postpartum (n = 20) and healthy non-pregnant women (n = 20). The results obtained were correlated with biochemical, hormonal and anthropometric variables and insulin resistance indices. Results: Levels of ANGPTL3 were not different between the follicular and the luteal phases of the cycle in healthy non-pregnant women. There was a significant reduction in serum ANGPTL3 levels from the first to the third trimester in healthy pregnant women compared with healthy non-pregnant and postpartum women (p 0.05) Conclusions: We describe for the first time the profile of ANGPTL3 throughout pregnancy and postpartum as well as and discussed about explore their potential contribution interactions with lipoprotein metabolism throughout pregnancy and postpartum. Thus, low levels of ANGPTL3 during pregnancy might favor lipid uptake in oxidative tissues as the main maternal energy source, while may helping to preserve glucose for use by the fetus and placenta. |
| format |
Articulo Articulo |
| author |
Garcés, María Fernanda Rodriguez Navarro, Haiver Antonio Buell Acosta, Julieth Daniela Burgos Cardenas, Alvaro Javier Franco Vega, Roberto Maldonado Acosta, Luis Miguel Eslava Schmalbach, Javier Parada Baños, Arturo José Castro Pinzon, Andres Sanchez, Elizabeth Ángel Müller, Edith Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Ruiz Parra, Ariel Iván Caminos, Jorge E. |
| author_facet |
Garcés, María Fernanda Rodriguez Navarro, Haiver Antonio Buell Acosta, Julieth Daniela Burgos Cardenas, Alvaro Javier Franco Vega, Roberto Maldonado Acosta, Luis Miguel Eslava Schmalbach, Javier Parada Baños, Arturo José Castro Pinzon, Andres Sanchez, Elizabeth Ángel Müller, Edith Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Ruiz Parra, Ariel Iván Caminos, Jorge E. |
| author_sort |
Garcés, María Fernanda |
| title |
Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women |
| title_short |
Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women |
| title_full |
Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women |
| title_fullStr |
Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women |
| title_full_unstemmed |
Maternal Serum Angiopoietin-Like 3 Levels in Healthy and Mild Preeclamptic Pregnant Women |
| title_sort |
maternal serum angiopoietin-like 3 levels in healthy and mild preeclamptic pregnant women |
| publishDate |
2021 |
| url |
http://sedici.unlp.edu.ar/handle/10915/124865 |
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