Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis

Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal gluco...

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Detalles Bibliográficos
Autores principales: Gagliardino, Juan José, Salazar, Martín R., Espeche, Walter Gastón, Tolosa Chapasian, Paula, Gomez Garizoain, Daniela, Olano, Ricardo Daniel, Stavile, Rodolfo Nicolás, Balbín, Eduardo, Martínez, Camilo, Leiva Sisnieguez, Betty Cecilia, Leiva Sisnieguez, Carlos Enrique, Carbajal, Horacio Antonio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Ciencias Médicas
pulse wave velocity
OGTT
prediabetes
TG/HDL ratio
dyslipidemia
arterial stiffness
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124828
https://www.mdpi.com/2077-0383/10/15/3251
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal glucose tolerance (NGT) or PreD. In each subgroup we also identified those with/out insulin resistance (IR) measured by the triglyceride/HDL-c ratio (normal cut off values previously established in our population). Clinical and metabolic data were collected for all participants. PWV was compared between subgroups using independent t test. Results: Women and men had comparable clinical and metabolic characteristics with obesity (BMI ≥ 30) and antihypertensive-statin treatment, almost half with either NGT or PreD. Whereas 48% of NGT people presented IR (abnormally high TG/HDL-c ratio), 52% had PreD. PWV was significantly higher only in those with a complete picture of metabolic syndrome (MS). Conclusions: Since PWV was significantly impaired in people with a complete picture of MS, clinicians must carefully search for early diagnosis of this condition and prescribe a healthy life-style to prevent development/progression of CVD. This proactive attitude would provide a cost-effective preventive strategy to avoid CVD’s negative impact on patients’ quality of life and on health systems due to their higher care costs.

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