Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice

Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet. For this purpose, we used a compilation of HF intake data from an experimental protocol...

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Autores principales:	De Francesco, Pablo Nicolás, Cornejo, María Paula, Barrile, Franco, García Romero, Guadalupe, Valdivia Torres, Lesly Spring, Andreoli, Maria Florencia, Perelló, Mario Carlos
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2019
Materias:	Ciencias Exactas Biología Ciencias Médicas food intake inter-individuality palatable foods eating behaviors obesity
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/124765
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-124765
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Exactas Biología Ciencias Médicas food intake inter-individuality palatable foods eating behaviors obesity
spellingShingle	Ciencias Exactas Biología Ciencias Médicas food intake inter-individuality palatable foods eating behaviors obesity De Francesco, Pablo Nicolás Cornejo, María Paula Barrile, Franco García Romero, Guadalupe Valdivia Torres, Lesly Spring Andreoli, Maria Florencia Perelló, Mario Carlos Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice
topic_facet	Ciencias Exactas Biología Ciencias Médicas food intake inter-individuality palatable foods eating behaviors obesity
description	Since inbred C57BL/6 mice are known to show inter-individual phenotypic variability for some traits, we tested the hypothesis that inbred C57BL/6 mice display a different tendency to consume a high fat (HF) diet. For this purpose, we used a compilation of HF intake data from an experimental protocol in which satiated mice were exposed to a HF pellet every morning for 2-h over 4 consecutive days. We found that mice displayed a large degree of variability in HF intake. Since day 1 HF intake significantly correlated with HF intake in successive days, we applied a hierarchical clustering algorithm on HF intake measurements in days 2, 3, and 4 in order to classify mice into "low" or "high" HF intake groups. "Low" HF intake group showed a day 1 HF intake similar to that seen in mice exposed to regular chow, while "high" HF intake group showed a higher day 1 HF intake as compared to "low" HF intake group. Both groups of mice increased HF consumption over the successive days, but "high" HF intake group always displayed a higher HF consumption than the "low" HF intake group. As compared to "low" HF intake group, "high" HF intake group showed a higher number of dopamine neurons positive for c-Fos in the VTA after the last event of HF intake. Thus, inbred C57BL/6 mice show inter-individual variability for HF intake and such feature may be linked to a different response to the rewarding properties of the HF diet.
format	Articulo Articulo
author	De Francesco, Pablo Nicolás Cornejo, María Paula Barrile, Franco García Romero, Guadalupe Valdivia Torres, Lesly Spring Andreoli, Maria Florencia Perelló, Mario Carlos
author_facet	De Francesco, Pablo Nicolás Cornejo, María Paula Barrile, Franco García Romero, Guadalupe Valdivia Torres, Lesly Spring Andreoli, Maria Florencia Perelló, Mario Carlos
author_sort	De Francesco, Pablo Nicolás
title	Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice
title_short	Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice
title_full	Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice
title_fullStr	Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice
title_full_unstemmed	Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice
title_sort	inter-individual variability for high fat diet consumption in inbred c57bl/6 mice
publishDate	2019
url	http://sedici.unlp.edu.ar/handle/10915/124765
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Inter-individual Variability for High Fat Diet Consumption in Inbred C57BL/6 Mice

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