Anandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor

The onset of labor involves the action of multiple factors and recent reports have postulated the endocannabinoid system as a new regulator of this process. Our objective was to study the role of anandamide, one of the main endocannabinoids, on the regulation of placental molecules that contribute t...

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Detalles Bibliográficos
Autores principales: Accialini, Paula, Abán, Cyntia, Etcheverry, Tomás, Negri Malbrán, Mercedes, Leguizamón, Gustavo, Herlax, Vanesa Silvana, Maté, Sabina María, Farina, Mariana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2021
Materias:
Medicina
Bioquímica
anandamide
prostaglandins
nitric oxide synthase
Placenta
labor
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124686
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-124686
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Bioquímica
anandamide
prostaglandins
nitric oxide synthase
Placenta
labor
spellingShingle Medicina
Bioquímica
anandamide
prostaglandins
nitric oxide synthase
Placenta
labor
Accialini, Paula
Abán, Cyntia
Etcheverry, Tomás
Negri Malbrán, Mercedes
Leguizamón, Gustavo
Herlax, Vanesa Silvana
Maté, Sabina María
Farina, Mariana
Anandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor
topic_facet Medicina
Bioquímica
anandamide
prostaglandins
nitric oxide synthase
Placenta
labor
description The onset of labor involves the action of multiple factors and recent reports have postulated the endocannabinoid system as a new regulator of this process. Our objective was to study the role of anandamide, one of the main endocannabinoids, on the regulation of placental molecules that contribute to the onset of labor at term. Placental samples were obtained from patients with laboring vaginal deliveries and from non-laboring elective cesarean sections. Vaginal delivery placentas produced higher prostaglandins levels than cesarean section samples. Besides, no differences were observed in NOS basal activity between groups. Incubation of vaginal delivery placentas with anandamide increased prostaglandins concentration and decreased NOS activity. Antagonism of type-1cannabinoid receptor (CB1) did not alter the effect observed on NOS activity. Conversely, incubation of cesarean section placentas with anandamide reduced prostaglandins levels and enhanced NOS activity, the latter involving the participation of CB1. Furthermore, we observed a differential expression of the main components of the endocannabinoid system between placental samples, being the change in CB1 localization the most relevant finding. Our results suggest that anandamide acts as a modulator of the signals that regulate labor, exerting differential actions depending on CB1 localization in laboring or non-laboring term placentas.
format Articulo
Articulo
author Accialini, Paula
Abán, Cyntia
Etcheverry, Tomás
Negri Malbrán, Mercedes
Leguizamón, Gustavo
Herlax, Vanesa Silvana
Maté, Sabina María
Farina, Mariana
author_facet Accialini, Paula
Abán, Cyntia
Etcheverry, Tomás
Negri Malbrán, Mercedes
Leguizamón, Gustavo
Herlax, Vanesa Silvana
Maté, Sabina María
Farina, Mariana
author_sort Accialini, Paula
title Anandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor
title_short Anandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor
title_full Anandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor
title_fullStr Anandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor
title_full_unstemmed Anandamide Exerts a Differential Effect on Human Placenta Before and After the Onset of Labor
title_sort anandamide exerts a differential effect on human placenta before and after the onset of labor
publishDate 2021
url http://sedici.unlp.edu.ar/handle/10915/124686
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