The surface chemistry of near-infrared resonant gold nanotriangles obtained via thiosulfate synthesis

Gold nanoparticles with NIR absorption are promising for photothermal therapy applications. Different syntheses have been proposed and, among them, that based on the reduction of Au(III) with thiosulfate is important because it yields gold nanotriangles (AuNTs) with strong absorption in the near-inf...

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Autores principales: Huergo, María Ana Cristina, Giovanetti, Lisandro José, Rubert, Aldo Alberto, Grillo, Claudia Alejandra, Moreno, Mario Sergio, Requejo, Félix Gregorio, Salvarezza, Roberto Carlos, Vericat, Carolina
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2019
Materias:
Química
Gold nanoparticles
Near infrared
Photothermal therapies
Thiosulfate
Reduced S species
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124659
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-124659
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Gold nanoparticles
Near infrared
Photothermal therapies
Thiosulfate
Reduced S species
spellingShingle Química
Gold nanoparticles
Near infrared
Photothermal therapies
Thiosulfate
Reduced S species
Huergo, María Ana Cristina
Giovanetti, Lisandro José
Rubert, Aldo Alberto
Grillo, Claudia Alejandra
Moreno, Mario Sergio
Requejo, Félix Gregorio
Salvarezza, Roberto Carlos
Vericat, Carolina
The surface chemistry of near-infrared resonant gold nanotriangles obtained via thiosulfate synthesis
topic_facet Química
Gold nanoparticles
Near infrared
Photothermal therapies
Thiosulfate
Reduced S species
description Gold nanoparticles with NIR absorption are promising for photothermal therapy applications. Different syntheses have been proposed and, among them, that based on the reduction of Au(III) with thiosulfate is important because it yields gold nanotriangles (AuNTs) with strong absorption in the near-infrared region. It has been previously reported by others that the nanoparticle surface is covered by relatively weak adsorbed S species (mostly sulfate), which would render the surface easy to functionalize in order to improve biocompatibility and therapeutic effects. In this work we have used XPS, XANES, UV–vis–NIR spectroscopy, HRTEM and AFM to demonstrate that, in contrast to the previous reports, these AuNTs are covered by strongly adsorbed sulfur species (sulfide and polysulfide). A reaction pathway is proposed to explain the presence of reduced sulfur species and the absence of adsorbed sulfates and thiosulfates. Preliminary cytotoxicity assays show that the S-capped AuNTs do not show a deleterious effect for Au concentrations larger than those needed for in vivo photothermal treatments.
format Articulo
Preprint
author Huergo, María Ana Cristina
Giovanetti, Lisandro José
Rubert, Aldo Alberto
Grillo, Claudia Alejandra
Moreno, Mario Sergio
Requejo, Félix Gregorio
Salvarezza, Roberto Carlos
Vericat, Carolina
author_facet Huergo, María Ana Cristina
Giovanetti, Lisandro José
Rubert, Aldo Alberto
Grillo, Claudia Alejandra
Moreno, Mario Sergio
Requejo, Félix Gregorio
Salvarezza, Roberto Carlos
Vericat, Carolina
author_sort Huergo, María Ana Cristina
title The surface chemistry of near-infrared resonant gold nanotriangles obtained via thiosulfate synthesis
title_short The surface chemistry of near-infrared resonant gold nanotriangles obtained via thiosulfate synthesis
title_full The surface chemistry of near-infrared resonant gold nanotriangles obtained via thiosulfate synthesis
title_fullStr The surface chemistry of near-infrared resonant gold nanotriangles obtained via thiosulfate synthesis
title_full_unstemmed The surface chemistry of near-infrared resonant gold nanotriangles obtained via thiosulfate synthesis
title_sort surface chemistry of near-infrared resonant gold nanotriangles obtained via thiosulfate synthesis
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/124659
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