Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy

Polyamine-salt aggregates (PSA) are biomimetic soft materials that have attracted great attention due to their straightforward fabrication methods, high drug-loading efficiencies, and attractive properties for pH-triggered release. Herein, a simple and fast multicomponent self-assembly process was u...

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Autores principales: Agazzi, Maximiliano Luis, Herrera, Santiago Esteban, Cortez, María Lorena, Marmisollé, Waldemar Alejandro, Azzaroni, Omar
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Ciencias Exactas
Química
drug delivery
molecular recognition
nanostructures
self-assembly
supramolecular chemistry
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124628
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-124628
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Química
drug delivery
molecular recognition
nanostructures
self-assembly
supramolecular chemistry
spellingShingle Ciencias Exactas
Química
drug delivery
molecular recognition
nanostructures
self-assembly
supramolecular chemistry
Agazzi, Maximiliano Luis
Herrera, Santiago Esteban
Cortez, María Lorena
Marmisollé, Waldemar Alejandro
Azzaroni, Omar
Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy
topic_facet Ciencias Exactas
Química
drug delivery
molecular recognition
nanostructures
self-assembly
supramolecular chemistry
description Polyamine-salt aggregates (PSA) are biomimetic soft materials that have attracted great attention due to their straightforward fabrication methods, high drug-loading efficiencies, and attractive properties for pH-triggered release. Herein, a simple and fast multicomponent self-assembly process was used to construct cross-linked poly(allylamine hydrochloride)/phosphate PSAs (hydrodynamic diameter of 360 nm) containing glucose oxidase enzyme, as a glucose-responsive element, and human recombinant insulin, as a therapeutic agent for the treatment of diabetes mellitus (GI-PSA). The addition of increasing glucose concentrations promotes the release of insulin due to the disassembly of the GI-PSAs triggered by the catalytic in situ formation of gluconic acid. Under normoglycemia, the GI-PSA integrity remained intact for at least 24 h, whereas hyperglycemic conditions resulted in 100 % cargo release after 4 h of glucose addition. This entirely supramolecular strategy presents great potential for the construction of smart glucose-responsive delivery nanocarriers.
format Articulo
Articulo
author Agazzi, Maximiliano Luis
Herrera, Santiago Esteban
Cortez, María Lorena
Marmisollé, Waldemar Alejandro
Azzaroni, Omar
author_facet Agazzi, Maximiliano Luis
Herrera, Santiago Esteban
Cortez, María Lorena
Marmisollé, Waldemar Alejandro
Azzaroni, Omar
author_sort Agazzi, Maximiliano Luis
title Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy
title_short Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy
title_full Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy
title_fullStr Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy
title_full_unstemmed Insulin Delivery from Glucose-Responsive, Self-Assembled, Polyamine Nanoparticles: Smart "Sense-and-Treat" Nanocarriers Made Easy
title_sort insulin delivery from glucose-responsive, self-assembled, polyamine nanoparticles: smart "sense-and-treat" nanocarriers made easy
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/124628
work_keys_str_mv AT agazzimaximilianoluis insulindeliveryfromglucoseresponsiveselfassembledpolyaminenanoparticlessmartsenseandtreatnanocarriersmadeeasy
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bdutipo_str Repositorios
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