Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits
Diverse immunoregulatory circuits operate to preserve intestinal homeostasis and prevent inflammation. Galectin-1 (Gal1), a β-galactoside-binding protein, promotes homeostasis by reprogramming innate and adaptive immunity. Here, we identify a glycosylation-dependent "on-off" circuit driven...
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| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2021
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/124604 |
| Aporte de: |
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I19-R120-10915-124604 |
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dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Medicina Ciencias Exactas intestinal homeostasis proteins inflammatory bowel disease (IBD) |
| spellingShingle |
Medicina Ciencias Exactas intestinal homeostasis proteins inflammatory bowel disease (IBD) Morosi, Luciano Gastón Cutine, Anabela M. Cagnoni, Alejandro J. Manselle Cocco, Montana N. Merlo, Joaquín P. Morales, Rosa M. May, María Pérez Sáez, Juan M. Girotti, María Romina Méndez Huergo, Santiago P. Pucci, Betiana Gil, Aníbal H. Huernos, Sergio P. Docena, Guillermo Horacio Sambuelli, Alicia M. Toscano, Marta A. Rabinovich, Gabriel A. Mariño, Karina V. Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits |
| topic_facet |
Medicina Ciencias Exactas intestinal homeostasis proteins inflammatory bowel disease (IBD) |
| description |
Diverse immunoregulatory circuits operate to preserve intestinal homeostasis and prevent inflammation. Galectin-1 (Gal1), a β-galactoside-binding protein, promotes homeostasis by reprogramming innate and adaptive immunity. Here, we identify a glycosylation-dependent "on-off" circuit driven by Gal1 and its glycosylated ligands that controls intestinal immunopathology by targeting activated CD8⁺ T cells and shaping the cytokine profile. In patients with inflammatory bowel disease (IBD), augmented Gal1 was associated with dysregulated expression of core 2 β6-N-acetylglucosaminyltransferase 1 (C2GNT1) and α(2,6)-sialyltransferase 1 (ST6GAL1), glycosyltransferases responsible for creating or masking Gal1 ligands. Mice lacking Gal1 exhibited exacerbated colitis and augmented mucosal CD8⁺ T cell activation in response to 2,4,6-trinitrobenzenesulfonic acid; this phenotype was partially ameliorated by treatment with recombinant Gal1. While C2gnt1<sup>-/-</sup> mice exhibited aggravated colitis, St6gal1<sup>-/-</sup> mice showed attenuated inflammation. These effects were associated with intrinsic T cell glycosylation. Thus, Gal1 and its glycosylated ligands act to preserve intestinal homeostasis by recalibrating T cell immunity. |
| format |
Articulo Articulo |
| author |
Morosi, Luciano Gastón Cutine, Anabela M. Cagnoni, Alejandro J. Manselle Cocco, Montana N. Merlo, Joaquín P. Morales, Rosa M. May, María Pérez Sáez, Juan M. Girotti, María Romina Méndez Huergo, Santiago P. Pucci, Betiana Gil, Aníbal H. Huernos, Sergio P. Docena, Guillermo Horacio Sambuelli, Alicia M. Toscano, Marta A. Rabinovich, Gabriel A. Mariño, Karina V. |
| author_facet |
Morosi, Luciano Gastón Cutine, Anabela M. Cagnoni, Alejandro J. Manselle Cocco, Montana N. Merlo, Joaquín P. Morales, Rosa M. May, María Pérez Sáez, Juan M. Girotti, María Romina Méndez Huergo, Santiago P. Pucci, Betiana Gil, Aníbal H. Huernos, Sergio P. Docena, Guillermo Horacio Sambuelli, Alicia M. Toscano, Marta A. Rabinovich, Gabriel A. Mariño, Karina V. |
| author_sort |
Morosi, Luciano Gastón |
| title |
Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits |
| title_short |
Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits |
| title_full |
Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits |
| title_fullStr |
Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits |
| title_full_unstemmed |
Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits |
| title_sort |
control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits |
| publishDate |
2021 |
| url |
http://sedici.unlp.edu.ar/handle/10915/124604 |
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Repositorios |
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1764820450722971648 |