Congenital Zika syndrome is associated with maternal protein malnutrition

Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevan...

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Detalles Bibliográficos
Autor principal: Barbeito, Claudio Gustavo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Medicina
Biología
Zika virus
Malnutrition
Pregnancy
Epidemiology
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124439
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-124439
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
Biología
Zika virus
Malnutrition
Pregnancy
Epidemiology
spellingShingle Medicina
Biología
Zika virus
Malnutrition
Pregnancy
Epidemiology
Barbeito, Claudio Gustavo
Congenital Zika syndrome is associated with maternal protein malnutrition
topic_facet Medicina
Biología
Zika virus
Malnutrition
Pregnancy
Epidemiology
description Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS.
format Articulo
Articulo
author Barbeito, Claudio Gustavo
author_facet Barbeito, Claudio Gustavo
author_sort Barbeito, Claudio Gustavo
title Congenital Zika syndrome is associated with maternal protein malnutrition
title_short Congenital Zika syndrome is associated with maternal protein malnutrition
title_full Congenital Zika syndrome is associated with maternal protein malnutrition
title_fullStr Congenital Zika syndrome is associated with maternal protein malnutrition
title_full_unstemmed Congenital Zika syndrome is associated with maternal protein malnutrition
title_sort congenital zika syndrome is associated with maternal protein malnutrition
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/124439
work_keys_str_mv AT barbeitoclaudiogustavo congenitalzikasyndromeisassociatedwithmaternalproteinmalnutrition
bdutipo_str Repositorios
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