C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases

A small series of C-glycosides containing the methoxyaryl moieties was tested for the inhibition of the β-class carbonic anhydrases (CAs, EC 4.2.1.1) from <i>Cryptococcus neoformans</i> and <i>Brucella suis</i>. Many compounds showed activities in the micromolar or submicromo...

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Autores principales: Riafrecha, Leonardo Ezequiel, Vullo, Daniela, Supuran, Claudiu T., Colinas, Pedro Alfonso
Formato: Articulo
Lenguaje:Inglés
Publicado: 2014
Materias:
Ciencias Exactas
Carbohydrate
carbonic anhydrase
pathogen
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/124089
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-124089
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Carbohydrate
carbonic anhydrase
pathogen
spellingShingle Ciencias Exactas
Carbohydrate
carbonic anhydrase
pathogen
Riafrecha, Leonardo Ezequiel
Vullo, Daniela
Supuran, Claudiu T.
Colinas, Pedro Alfonso
C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases
topic_facet Ciencias Exactas
Carbohydrate
carbonic anhydrase
pathogen
description A small series of C-glycosides containing the methoxyaryl moieties was tested for the inhibition of the β-class carbonic anhydrases (CAs, EC 4.2.1.1) from <i>Cryptococcus neoformans</i> and <i>Brucella suis</i>. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes. The deprotected glycosides incorporating the 6-methoxy-2-naphthyl moiety showed the best inhibition profile and therefore represent leads for the development of novel anti-infectives with a new mechanism of action.
format Articulo
Articulo
author Riafrecha, Leonardo Ezequiel
Vullo, Daniela
Supuran, Claudiu T.
Colinas, Pedro Alfonso
author_facet Riafrecha, Leonardo Ezequiel
Vullo, Daniela
Supuran, Claudiu T.
Colinas, Pedro Alfonso
author_sort Riafrecha, Leonardo Ezequiel
title C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases
title_short C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases
title_full C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases
title_fullStr C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases
title_full_unstemmed C-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases
title_sort c-glycosides incorporating the 6-methoxy-2-naphthyl moiety are selective inhibitors of fungal and bacterial carbonic anhydrases
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/124089
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