Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety

A small series of C-glycosides containing the phenol moiety was tested for the inhibition of the β-class carbonic anhydrases (βCAs, EC 4.2.1.1) from Brucella suis. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes...

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Autores principales: Riafrecha, Leonardo Ezequiel, Vullo, Daniela, Ouahrani-Bettache, Safia, Köhler, Stephan, Dumy, Pascal, Winum, Jean-Yves, Supuran, Claudiu T., Colinas, Pedro Alfonso
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2015
Materias:
Química
Antibacterial
Carbohydrate
Carbonic anhydrase
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/123774
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-123774
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Antibacterial
Carbohydrate
Carbonic anhydrase
spellingShingle Química
Antibacterial
Carbohydrate
Carbonic anhydrase
Riafrecha, Leonardo Ezequiel
Vullo, Daniela
Ouahrani-Bettache, Safia
Köhler, Stephan
Dumy, Pascal
Winum, Jean-Yves
Supuran, Claudiu T.
Colinas, Pedro Alfonso
Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety
topic_facet Química
Antibacterial
Carbohydrate
Carbonic anhydrase
description A small series of C-glycosides containing the phenol moiety was tested for the inhibition of the β-class carbonic anhydrases (βCAs, EC 4.2.1.1) from Brucella suis. Many compounds showed activities in the micromolar or submicromolar range and excellent selectivity for pathogen CAs over human isozymes. Glycosides incorporating the 3-hydroxyphenyl moiety showed the best inhibition profile, and therefore this functionality represents lead for the development of novel anti-infectives with a new mechanism of action.
format Articulo
Comunicacion
author Riafrecha, Leonardo Ezequiel
Vullo, Daniela
Ouahrani-Bettache, Safia
Köhler, Stephan
Dumy, Pascal
Winum, Jean-Yves
Supuran, Claudiu T.
Colinas, Pedro Alfonso
author_facet Riafrecha, Leonardo Ezequiel
Vullo, Daniela
Ouahrani-Bettache, Safia
Köhler, Stephan
Dumy, Pascal
Winum, Jean-Yves
Supuran, Claudiu T.
Colinas, Pedro Alfonso
author_sort Riafrecha, Leonardo Ezequiel
title Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety
title_short Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety
title_full Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety
title_fullStr Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety
title_full_unstemmed Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety
title_sort inhibition of β-carbonic anhydrases from brucella suis with c-cinnamoyl glycosides incorporating the phenol moiety
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/123774
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