Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells

Vanadium is a trace element widely distributed in the environment. In vertebrates it is mainly stored in bone tissue. The unique cellular environment in the bone and the variety of interactions that mediate cancer metastasis determine that certain types of cancer, such as breast and prostate cancer,...

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Detalles Bibliográficos
Autores principales: Molinuevo, María Silvina, Cortizo, Ana María, Etcheverry, Susana Beatriz
Formato: Articulo
Lenguaje:Inglés
Publicado: 2008
Materias:
Ciencias Exactas
Bioquímica
Vanadium
Cancer
Metastasis
Osteosarcoma
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/123725
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-123725
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Bioquímica
Vanadium
Cancer
Metastasis
Osteosarcoma
spellingShingle Ciencias Exactas
Bioquímica
Vanadium
Cancer
Metastasis
Osteosarcoma
Molinuevo, María Silvina
Cortizo, Ana María
Etcheverry, Susana Beatriz
Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
topic_facet Ciencias Exactas
Bioquímica
Vanadium
Cancer
Metastasis
Osteosarcoma
description Vanadium is a trace element widely distributed in the environment. In vertebrates it is mainly stored in bone tissue. The unique cellular environment in the bone and the variety of interactions that mediate cancer metastasis determine that certain types of cancer, such as breast and prostate cancer, preferentially metastize in the skeleton. Since this effect usually signifies serious morbidity and grave prognosis there is an increasing interest in the development of new treatments for this pathology. The present work shows that vanadium complexes can inhibit some parameters related to cancer metastasis such as cell adhesion, migration and clonogenicity. We have also investigated the role of protein kinase A in these processes.
format Articulo
Articulo
author Molinuevo, María Silvina
Cortizo, Ana María
Etcheverry, Susana Beatriz
author_facet Molinuevo, María Silvina
Cortizo, Ana María
Etcheverry, Susana Beatriz
author_sort Molinuevo, María Silvina
title Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_short Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_full Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_fullStr Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_full_unstemmed Vanadium(IV) complexes inhibit adhesion, migration and colony formation of UMR106 osteosarcoma cells
title_sort vanadium(iv) complexes inhibit adhesion, migration and colony formation of umr106 osteosarcoma cells
publishDate 2008
url http://sedici.unlp.edu.ar/handle/10915/123725
work_keys_str_mv AT molinuevomariasilvina vanadiumivcomplexesinhibitadhesionmigrationandcolonyformationofumr106osteosarcomacells
AT cortizoanamaria vanadiumivcomplexesinhibitadhesionmigrationandcolonyformationofumr106osteosarcomacells
AT etcheverrysusanabeatriz vanadiumivcomplexesinhibitadhesionmigrationandcolonyformationofumr106osteosarcomacells
bdutipo_str Repositorios
_version_ 1764820450131574785

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