A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer
A new dinuclear complex of formula [{Re(CO)₃(py)}₂(μ-4,4”-azobpy)](PF₆)₂, with py = pyridine and 4,4”-azobpy = 4,4”-azobis(2,2’-bipyridine), has been synthesized and characterized by spectroscopic and electrochemical techniques. The symmetrical nature of the dimetallic cation has been confirmed by n...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2020
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/123623 |
| Aporte de: |
| id |
I19-R120-10915-123623 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Exactas Química rhenium thiol detection chemotherapy |
| spellingShingle |
Ciencias Exactas Química rhenium thiol detection chemotherapy Abate, Pedro Oscar Sottile, Marco León, Ignacio Esteban Vergara, Mónica M. Katz, Néstor E. A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| topic_facet |
Ciencias Exactas Química rhenium thiol detection chemotherapy |
| description |
A new dinuclear complex of formula [{Re(CO)₃(py)}₂(μ-4,4”-azobpy)](PF₆)₂, with py = pyridine and 4,4”-azobpy = 4,4”-azobis(2,2’-bipyridine), has been synthesized and characterized by spectroscopic and electrochemical techniques. The symmetrical nature of the dimetallic cation has been confirmed by nuclear magnetic resonance (NMR) measurements. When adding L-cysteine or L-glutathione, large and rapid changes in its UV-Vis absorption spectra were observed, which can be used for detecting both biologically relevant thiols. A promising activity for using this complex as a chemotherapeutic agent for bone cancer was also disclosed. Quantum mechanical calculations supported the experimental data. |
| format |
Articulo Articulo |
| author |
Abate, Pedro Oscar Sottile, Marco León, Ignacio Esteban Vergara, Mónica M. Katz, Néstor E. |
| author_facet |
Abate, Pedro Oscar Sottile, Marco León, Ignacio Esteban Vergara, Mónica M. Katz, Néstor E. |
| author_sort |
Abate, Pedro Oscar |
| title |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| title_short |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| title_full |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| title_fullStr |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| title_full_unstemmed |
A Symmetrical Dirhenium(I) Complex with 4,4’’-Azobis(2,2’-bipyridine) as a Bridging Ligand: Synthesis, Physicochemical Properties and Applications in Detection of Biologically Relevant Thiols and in Chemotherapy for Bone Cancer |
| title_sort |
symmetrical dirhenium(i) complex with 4,4’’-azobis(2,2’-bipyridine) as a bridging ligand: synthesis, physicochemical properties and applications in detection of biologically relevant thiols and in chemotherapy for bone cancer |
| publishDate |
2020 |
| url |
http://sedici.unlp.edu.ar/handle/10915/123623 |
| work_keys_str_mv |
AT abatepedrooscar asymmetricaldirheniumicomplexwith44azobis22bipyridineasabridgingligandsynthesisphysicochemicalpropertiesandapplicationsindetectionofbiologicallyrelevantthiolsandinchemotherapyforbonecancer AT sottilemarco asymmetricaldirheniumicomplexwith44azobis22bipyridineasabridgingligandsynthesisphysicochemicalpropertiesandapplicationsindetectionofbiologicallyrelevantthiolsandinchemotherapyforbonecancer AT leonignacioesteban asymmetricaldirheniumicomplexwith44azobis22bipyridineasabridgingligandsynthesisphysicochemicalpropertiesandapplicationsindetectionofbiologicallyrelevantthiolsandinchemotherapyforbonecancer AT vergaramonicam asymmetricaldirheniumicomplexwith44azobis22bipyridineasabridgingligandsynthesisphysicochemicalpropertiesandapplicationsindetectionofbiologicallyrelevantthiolsandinchemotherapyforbonecancer AT katznestore asymmetricaldirheniumicomplexwith44azobis22bipyridineasabridgingligandsynthesisphysicochemicalpropertiesandapplicationsindetectionofbiologicallyrelevantthiolsandinchemotherapyforbonecancer AT abatepedrooscar symmetricaldirheniumicomplexwith44azobis22bipyridineasabridgingligandsynthesisphysicochemicalpropertiesandapplicationsindetectionofbiologicallyrelevantthiolsandinchemotherapyforbonecancer AT sottilemarco symmetricaldirheniumicomplexwith44azobis22bipyridineasabridgingligandsynthesisphysicochemicalpropertiesandapplicationsindetectionofbiologicallyrelevantthiolsandinchemotherapyforbonecancer AT leonignacioesteban symmetricaldirheniumicomplexwith44azobis22bipyridineasabridgingligandsynthesisphysicochemicalpropertiesandapplicationsindetectionofbiologicallyrelevantthiolsandinchemotherapyforbonecancer AT vergaramonicam symmetricaldirheniumicomplexwith44azobis22bipyridineasabridgingligandsynthesisphysicochemicalpropertiesandapplicationsindetectionofbiologicallyrelevantthiolsandinchemotherapyforbonecancer AT katznestore symmetricaldirheniumicomplexwith44azobis22bipyridineasabridgingligandsynthesisphysicochemicalpropertiesandapplicationsindetectionofbiologicallyrelevantthiolsandinchemotherapyforbonecancer |
| bdutipo_str |
Repositorios |
| _version_ |
1764820449879916545 |