Kinetics of linoleic and arachidonic acid incorporation and eicosatrienoic depletion in the lipids of fat-deficient rats fed methyl linoleate and arachidonate

Changes induced by dietary methyl linoleate and arachidonate in the fatty acid composition of liver phosphatidyl choline, phosphatidyl ethanolamine, cholesterol esters, and triglycerides were investigated in essential fatty aciddeficient rats. The esters were fed for 0, 24, 50, 96, 192, and 360 hr....

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Autores principales:	Brenner, Rodolfo Roberto, Nervi, Aníbal Mario
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	1965
Materias:	Ciencias Médicas kinetics linoleic arachidonic incorporation eicosatrienoic depletion liver lipids rat choline glycerophosphatides ethanolamine phospholipase A triglycerides
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/123518
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-123518
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas kinetics linoleic arachidonic incorporation eicosatrienoic depletion liver lipids rat choline glycerophosphatides ethanolamine glycerophosphatides phospholipase A triglycerides
spellingShingle	Ciencias Médicas kinetics linoleic arachidonic incorporation eicosatrienoic depletion liver lipids rat choline glycerophosphatides ethanolamine glycerophosphatides phospholipase A triglycerides Brenner, Rodolfo Roberto Nervi, Aníbal Mario Kinetics of linoleic and arachidonic acid incorporation and eicosatrienoic depletion in the lipids of fat-deficient rats fed methyl linoleate and arachidonate
topic_facet	Ciencias Médicas kinetics linoleic arachidonic incorporation eicosatrienoic depletion liver lipids rat choline glycerophosphatides ethanolamine glycerophosphatides phospholipase A triglycerides
description	Changes induced by dietary methyl linoleate and arachidonate in the fatty acid composition of liver phosphatidyl choline, phosphatidyl ethanolamine, cholesterol esters, and triglycerides were investigated in essential fatty aciddeficient rats. The esters were fed for 0, 24, 50, 96, 192, and 360 hr. The lipids were fractionated by thin-layer chromatography and the fatty acid composition was estimated by gas liquid chromatography. Acids bound to the a'- and 8-carbons of phosphatides were separated by lipolysis with phospholipase A. From the compositions found it was deduced that both dietary linoleate and arachidonate inhibited eicosatrienoate synthesis from oleate but that only arachidonate replaced eicosatrienoate quantitatively in the 8-position of lecithin and cephalin. Both dietary acids displaced some of the &positioned oleate. Monoenoic: saturated acid ratios were also decreased by both esters both in triglycerides and in a'-bound acids in phosphatides. In triglycerides this change preceded any significant incorporation of linoleate or arachidonate. Arachidonate effects seemed to be more rapid and more marked than those of linoleate and although final compositions were similar, because of the conversion of linoleate into arachidonate, a different pattern of reactions led to these results.
format	Articulo Articulo
author	Brenner, Rodolfo Roberto Nervi, Aníbal Mario
author_facet	Brenner, Rodolfo Roberto Nervi, Aníbal Mario
author_sort	Brenner, Rodolfo Roberto
title	Kinetics of linoleic and arachidonic acid incorporation and eicosatrienoic depletion in the lipids of fat-deficient rats fed methyl linoleate and arachidonate
title_short	Kinetics of linoleic and arachidonic acid incorporation and eicosatrienoic depletion in the lipids of fat-deficient rats fed methyl linoleate and arachidonate
title_full	Kinetics of linoleic and arachidonic acid incorporation and eicosatrienoic depletion in the lipids of fat-deficient rats fed methyl linoleate and arachidonate
title_fullStr	Kinetics of linoleic and arachidonic acid incorporation and eicosatrienoic depletion in the lipids of fat-deficient rats fed methyl linoleate and arachidonate
title_full_unstemmed	Kinetics of linoleic and arachidonic acid incorporation and eicosatrienoic depletion in the lipids of fat-deficient rats fed methyl linoleate and arachidonate
title_sort	kinetics of linoleic and arachidonic acid incorporation and eicosatrienoic depletion in the lipids of fat-deficient rats fed methyl linoleate and arachidonate
publishDate	1965
url	http://sedici.unlp.edu.ar/handle/10915/123518
work_keys_str_mv	AT brennerrodolforoberto kineticsoflinoleicandarachidonicacidincorporationandeicosatrienoicdepletioninthelipidsoffatdeficientratsfedmethyllinoleateandarachidonate AT nervianibalmario kineticsoflinoleicandarachidonicacidincorporationandeicosatrienoicdepletioninthelipidsoffatdeficientratsfedmethyllinoleateandarachidonate
bdutipo_str	Repositorios
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Kinetics of linoleic and arachidonic acid incorporation and eicosatrienoic depletion in the lipids of fat-deficient rats fed methyl linoleate and arachidonate

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