Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test

This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± ...

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Autores principales:	Garcés, María Fernanda, Buell-Acosta, Julieth Daniela, Rodriguez-Navarro, Haiver Antonio, Pulido-Sánchez, Estefania, Rincon-Ramírez, Juan José, Moreno-Ordóñez, Diana Carolina, Franco-Vega, Roberto, Roncancio-Muñoz, Jhoan Sebastian, Burgos-Cardenas, Alvaro Javier, Lacunza, Ezequiel, Castaño, Justo P., Dieguez, Carlos, Nogueiras, Rubén, Sanchez, Elizabeth, Caminos, Jorge E.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2020
Materias:	Ciencias Médicas ANGPTL3 serum levels Glucose tolerance
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/123483
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-123483
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas ANGPTL3 serum levels Glucose tolerance
spellingShingle	Ciencias Médicas ANGPTL3 serum levels Glucose tolerance Garcés, María Fernanda Buell-Acosta, Julieth Daniela Rodriguez-Navarro, Haiver Antonio Pulido-Sánchez, Estefania Rincon-Ramírez, Juan José Moreno-Ordóñez, Diana Carolina Franco-Vega, Roberto Roncancio-Muñoz, Jhoan Sebastian Burgos-Cardenas, Alvaro Javier Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Sanchez, Elizabeth Caminos, Jorge E. Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
topic_facet	Ciencias Médicas ANGPTL3 serum levels Glucose tolerance
description	This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case–control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m<sup>2</sup>) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m<sup>2</sup>) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3–area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3–AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride—glucose index. Moreover, ANGPTL3–AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.
format	Articulo Articulo
author	Garcés, María Fernanda Buell-Acosta, Julieth Daniela Rodriguez-Navarro, Haiver Antonio Pulido-Sánchez, Estefania Rincon-Ramírez, Juan José Moreno-Ordóñez, Diana Carolina Franco-Vega, Roberto Roncancio-Muñoz, Jhoan Sebastian Burgos-Cardenas, Alvaro Javier Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Sanchez, Elizabeth Caminos, Jorge E.
author_facet	Garcés, María Fernanda Buell-Acosta, Julieth Daniela Rodriguez-Navarro, Haiver Antonio Pulido-Sánchez, Estefania Rincon-Ramírez, Juan José Moreno-Ordóñez, Diana Carolina Franco-Vega, Roberto Roncancio-Muñoz, Jhoan Sebastian Burgos-Cardenas, Alvaro Javier Lacunza, Ezequiel Castaño, Justo P. Dieguez, Carlos Nogueiras, Rubén Sanchez, Elizabeth Caminos, Jorge E.
author_sort	Garcés, María Fernanda
title	Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
title_short	Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
title_full	Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
title_fullStr	Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
title_full_unstemmed	Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
title_sort	serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
publishDate	2020
url	http://sedici.unlp.edu.ar/handle/10915/123483
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Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test

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