Synthesis and anticonvulsant activity of amino acid-derived sulfamides

Sulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimen...

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Autores principales: Gavernet, Luciana, Elvira, Juan E., Samaja, Gisela, Pastore, Valentina, Sella Cravero, Mariana, Enrique, Andrea Verónica, Estiú, Guillermina, Bruno Blanch, Luis Enrique
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Química
Sulfamides
Anticonvulsant compounds
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/123431
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-123431
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Sulfamides
Anticonvulsant compounds
spellingShingle Química
Sulfamides
Anticonvulsant compounds
Gavernet, Luciana
Elvira, Juan E.
Samaja, Gisela
Pastore, Valentina
Sella Cravero, Mariana
Enrique, Andrea Verónica
Estiú, Guillermina
Bruno Blanch, Luis Enrique
Synthesis and anticonvulsant activity of amino acid-derived sulfamides
topic_facet Química
Sulfamides
Anticonvulsant compounds
description Sulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).
format Articulo
Articulo
author Gavernet, Luciana
Elvira, Juan E.
Samaja, Gisela
Pastore, Valentina
Sella Cravero, Mariana
Enrique, Andrea Verónica
Estiú, Guillermina
Bruno Blanch, Luis Enrique
author_facet Gavernet, Luciana
Elvira, Juan E.
Samaja, Gisela
Pastore, Valentina
Sella Cravero, Mariana
Enrique, Andrea Verónica
Estiú, Guillermina
Bruno Blanch, Luis Enrique
author_sort Gavernet, Luciana
title Synthesis and anticonvulsant activity of amino acid-derived sulfamides
title_short Synthesis and anticonvulsant activity of amino acid-derived sulfamides
title_full Synthesis and anticonvulsant activity of amino acid-derived sulfamides
title_fullStr Synthesis and anticonvulsant activity of amino acid-derived sulfamides
title_full_unstemmed Synthesis and anticonvulsant activity of amino acid-derived sulfamides
title_sort synthesis and anticonvulsant activity of amino acid-derived sulfamides
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/123431
work_keys_str_mv AT gavernetluciana synthesisandanticonvulsantactivityofaminoacidderivedsulfamides
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