Risk of cardiovascular disease according to blood pressure categories in an argentinian cohort
Background: Hypertension is a recognized strong risk factor for cardiovascular disease. However, no data was available in our country to quantify the relationship between blood pressure and cardiovascular event. Objective: to quantify the risk of cardiovascular events according to blood pressure ca...
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2016
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/122123 |
| Aporte de: |
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I19-R120-10915-122123 |
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dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas Cardiovascular diseases Epidemiology General population High blood pressure Enfermedad cardiovascular Epidemiología Población general Presión sanguínea elevada |
| spellingShingle |
Ciencias Médicas Cardiovascular diseases Epidemiology General population High blood pressure Enfermedad cardiovascular Epidemiología Población general Presión sanguínea elevada Salazar, Martín R. Espeche, Walter Gastón Aizpurúa, Marcelo Leiva Sisnieguez, Betty Cecilia Leiva Sisnieguez, Carlos Enrique Dulbecco, Carlos Alberto Carbajal, Horacio Antonio Risk of cardiovascular disease according to blood pressure categories in an argentinian cohort |
| topic_facet |
Ciencias Médicas Cardiovascular diseases Epidemiology General population High blood pressure Enfermedad cardiovascular Epidemiología Población general Presión sanguínea elevada |
| description |
Background: Hypertension is a recognized strong risk factor for cardiovascular disease. However, no data was available in our country to quantify the relationship between blood pressure and cardiovascular event.
Objective: to quantify the risk of cardiovascular events according to blood pressure categories.
Methods: A prospective epidemiological study was conducted in 1526 inhabitants from Rauch City, (Buenos Aires, Argentina) between 1997 and 2012. Subjects were classified into one of these blood-pressure categories: 1-optimal, 2-normal, 3-high-normal, 4-grade 1 hypertension, 5-grade 2 hypertension and 6-grade 3 hypertension. The first CVD event, including unstable angina pectoris, fatal and non-fatal myocardial infarction, myocardial revascularization, and fatal or non-fatal stroke, was defined as the primary endpoint. Multivariable Cox proportional-hazards regression models were used to estimate the relative risk (HR) of CVD according to base-line blood-pressure categories.
Results: In 2012, 1124 individuals (73.7% of the baseline sample), 719 women and 405 men (in 1997, aged 45±16 and 46±16 respectively) or their relatives in case of death, could be surveyed again in order to obtain information concerning incident CVD events. Cardiovascular event rates and HR values increased in a stepwise manner across the blood pressure categories (p for trend across categories <0.001 in both sex); however, in subjects aged ≥55 years a j-curve phenomenon was observed, showing the lowest incidence in the high-normal category. In all categories CVD events rates were higher for men.
Conclusion: This study quantified relationships between BP and CVD starting from high-normal blood pressure in Argentina. |
| format |
Articulo Articulo |
| author |
Salazar, Martín R. Espeche, Walter Gastón Aizpurúa, Marcelo Leiva Sisnieguez, Betty Cecilia Leiva Sisnieguez, Carlos Enrique Dulbecco, Carlos Alberto Carbajal, Horacio Antonio |
| author_facet |
Salazar, Martín R. Espeche, Walter Gastón Aizpurúa, Marcelo Leiva Sisnieguez, Betty Cecilia Leiva Sisnieguez, Carlos Enrique Dulbecco, Carlos Alberto Carbajal, Horacio Antonio |
| author_sort |
Salazar, Martín R. |
| title |
Risk of cardiovascular disease according to blood pressure categories in an argentinian cohort |
| title_short |
Risk of cardiovascular disease according to blood pressure categories in an argentinian cohort |
| title_full |
Risk of cardiovascular disease according to blood pressure categories in an argentinian cohort |
| title_fullStr |
Risk of cardiovascular disease according to blood pressure categories in an argentinian cohort |
| title_full_unstemmed |
Risk of cardiovascular disease according to blood pressure categories in an argentinian cohort |
| title_sort |
risk of cardiovascular disease according to blood pressure categories in an argentinian cohort |
| publishDate |
2016 |
| url |
http://sedici.unlp.edu.ar/handle/10915/122123 |
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