Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions

Pharmacokinetic profile, tissue concentrations and urine elimination of cephalothin in cats under surgical conditions after a single intravenous dose (30 mg/kg) were studied. Initial plasma concentrations were high [Cp(0), 353.79±118.92 μg/mL], with fast and moderately wide distribution [T1⁄2(d) 0.1...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Albarellos, Gabriela A., Montoya, Laura, Lupi, Martín P., Passini, Sabrina M., Lorenzini, Paula, Landoni, María Fabiana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Veterinarias
Antimicrobials
Cephalosporins
Pharmacokinetics
Tissue concentrations
Cats
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/120562
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-120562
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Antimicrobials
Cephalosporins
Pharmacokinetics
Tissue concentrations
Cats
spellingShingle Ciencias Veterinarias
Antimicrobials
Cephalosporins
Pharmacokinetics
Tissue concentrations
Cats
Albarellos, Gabriela A.
Montoya, Laura
Lupi, Martín P.
Passini, Sabrina M.
Lorenzini, Paula
Landoni, María Fabiana
Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
topic_facet Ciencias Veterinarias
Antimicrobials
Cephalosporins
Pharmacokinetics
Tissue concentrations
Cats
description Pharmacokinetic profile, tissue concentrations and urine elimination of cephalothin in cats under surgical conditions after a single intravenous dose (30 mg/kg) were studied. Initial plasma concentrations were high [Cp(0), 353.79±118.92 μg/mL], with fast and moderately wide distribution [T1⁄2(d) 0.14±0.10 h] [V(d(ss)) 0.19±0.03 L/kg] and rapid elimination (ClB, 0.16±0.03 L/h.kg; T1⁄2, 1.07±0.23 h; MRT, 1.16±0.21 h). Thirty to 60 minutes after intravenous administration, cephalothin tissue concentrations were in the range of 3.73 μg/g (testicle tissue) to 25.63 μg/g (uterus). Tissue/plasma concentrations rate was in a range of 0.04 (testicle) to 0.21 (uterus). Cephalothin urine elimination was 66.49% in the first 6 hours after administration. Cephalothin plasma concentrations remained above a MIC≥1 μg/mL up to 5.5 hours in all the studied cats. However, for MIC≥8 –μg/mL (MIC breakpoint) this time is reduced to 2.5 hours. This suggests that proper perioperative prophylactic use of cephalothin in cats requires a dose interval not longer than 2 hours.
format Articulo
Articulo
author Albarellos, Gabriela A.
Montoya, Laura
Lupi, Martín P.
Passini, Sabrina M.
Lorenzini, Paula
Landoni, María Fabiana
author_facet Albarellos, Gabriela A.
Montoya, Laura
Lupi, Martín P.
Passini, Sabrina M.
Lorenzini, Paula
Landoni, María Fabiana
author_sort Albarellos, Gabriela A.
title Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
title_short Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
title_full Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
title_fullStr Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
title_full_unstemmed Plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
title_sort plasma pharmacokinetics, tissue concentrations and urine elimination after cephalothin intravenous administration to cats under surgical conditions
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/120562
work_keys_str_mv AT albarellosgabrielaa plasmapharmacokineticstissueconcentrationsandurineeliminationaftercephalothinintravenousadministrationtocatsundersurgicalconditions
AT montoyalaura plasmapharmacokineticstissueconcentrationsandurineeliminationaftercephalothinintravenousadministrationtocatsundersurgicalconditions
AT lupimartinp plasmapharmacokineticstissueconcentrationsandurineeliminationaftercephalothinintravenousadministrationtocatsundersurgicalconditions
AT passinisabrinam plasmapharmacokineticstissueconcentrationsandurineeliminationaftercephalothinintravenousadministrationtocatsundersurgicalconditions
AT lorenzinipaula plasmapharmacokineticstissueconcentrationsandurineeliminationaftercephalothinintravenousadministrationtocatsundersurgicalconditions
AT landonimariafabiana plasmapharmacokineticstissueconcentrationsandurineeliminationaftercephalothinintravenousadministrationtocatsundersurgicalconditions
bdutipo_str Repositorios
_version_ 1764820447906496515

Ejemplares similares