ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver

The in vivo and in vitro effect of ACTH on the biosynthesis of polyunsaturated fatty acid of rat adrenal gland and liver was studied. The administration of ACTH to intact rats produced a significant decrease in the conversion of [1-14C]linoleic acid to gamma-linolenic acid, [1-14C]alpha-linolenic ac...

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Autores principales:	Mandon, Elisabet C., Tacconi de Gómez Dumm, Irma Nelva, Tacconi de Alaniz, María Josefa, Marra, Carlos Alberto, Brenner, Rodolfo Roberto
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	1987
Materias:	Química Biología Linoleic acid α-linolenic acid Eicosa- 8,11,14-trienoic acid Polyunsaturated fatty acids Isolated adrenocortical cells Hepatocytes
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/120450
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-120450
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Química Biología Linoleic acid α-linolenic acid Eicosa- 8,11,14-trienoic acid Polyunsaturated fatty acids Isolated adrenocortical cells Hepatocytes
spellingShingle	Química Biología Linoleic acid α-linolenic acid Eicosa- 8,11,14-trienoic acid Polyunsaturated fatty acids Isolated adrenocortical cells Hepatocytes Mandon, Elisabet C. Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Marra, Carlos Alberto Brenner, Rodolfo Roberto ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver
topic_facet	Química Biología Linoleic acid α-linolenic acid Eicosa- 8,11,14-trienoic acid Polyunsaturated fatty acids Isolated adrenocortical cells Hepatocytes
description	The in vivo and in vitro effect of ACTH on the biosynthesis of polyunsaturated fatty acid of rat adrenal gland and liver was studied. The administration of ACTH to intact rats produced a significant decrease in the conversion of [1-14C]linoleic acid to gamma-linolenic acid, [1-14C]alpha-linolenic acid to octadeca-6,9,12,15-tetraenoic acid, and [1-14C]eicosa-8,11,14-trienoic acid to arachidonic acid in liver and adrenal microsomes. Isolated adrenocortical cells and hepatocytes obtained from animals treated with ACTH showed a decrease in the incorporation and desaturation of exogenous [1-14C]eicosa-8,11,14-trienoic acid. The addition of ACTH to the incubation medium of adrenocortical cells and hepatocytes isolated from untreated rats also caused a decrease in delta 5 desaturation activity. The effect of ACTH on adrenal and liver desaturases could be produced as a consequence of the release of glucocorticoids, already measured in the experiments. However, the in vitro experiments carried out with hepatocytes isolated from untreated rats, where corticosterone was absent, indicated that ACTH can depress delta 5 desaturation per se.
format	Articulo Articulo
author	Mandon, Elisabet C. Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Marra, Carlos Alberto Brenner, Rodolfo Roberto
author_facet	Mandon, Elisabet C. Tacconi de Gómez Dumm, Irma Nelva Tacconi de Alaniz, María Josefa Marra, Carlos Alberto Brenner, Rodolfo Roberto
author_sort	Mandon, Elisabet C.
title	ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver
title_short	ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver
title_full	ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver
title_fullStr	ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver
title_full_unstemmed	ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver
title_sort	acth depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver
publishDate	1987
url	http://sedici.unlp.edu.ar/handle/10915/120450
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bdutipo_str	Repositorios
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ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver

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