Biomarkers of prolonged exposure to microcystin-LR in mice

The effects of prolonged exposure to microcystins (MCs) on health are not yet sufficiently understood and this type of poisoning is often undiagnosed. Even though chronic exposure has been linked with liver cancer and alterations have been described in liver damage marker enzymes in exposed populati...

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Autores principales: Sedan, Daniela Yazmine, Giannuzzi, Leda, Rosso, Lorena, Marra, Carlos Alberto, Andrinolo, Darío
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Ciencias Exactas
Microcystins
Prolonged exposure
Biomarkers
Mice
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/120414
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-120414
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Microcystins
Prolonged exposure
Biomarkers
Mice
spellingShingle Ciencias Exactas
Microcystins
Prolonged exposure
Biomarkers
Mice
Sedan, Daniela Yazmine
Giannuzzi, Leda
Rosso, Lorena
Marra, Carlos Alberto
Andrinolo, Darío
Biomarkers of prolonged exposure to microcystin-LR in mice
topic_facet Ciencias Exactas
Microcystins
Prolonged exposure
Biomarkers
Mice
description The effects of prolonged exposure to microcystins (MCs) on health are not yet sufficiently understood and this type of poisoning is often undiagnosed. Even though chronic exposure has been linked with liver cancer and alterations have been described in liver damage marker enzymes in exposed populations, there are not profile parameters that indicate prolonged exposure to microcystins. The aim of this work is to determine, based on an animal model of prolonged exposure to successive i.p. doses of 25 mg MC-LR/kg body weight, several plasma parameters which could be useful as exposure biomarkers. Hemoglobin (Hb) and methemoglobin (MetHb) levels were determined on blood samples. We also studied plasma levels of hydroperoxides (ROOHs), a-tocopherol, glutathione and lipid profile as well as superoxide dismutase (SOD) and catalase (CAT) erythrocyte activities. In addition, the determination of MC-LR levels in liver, kidney, plasma, urine and feces of treated mice was carried out. We found that alteration in MetHb, ROOHs, glutathione, a-tocopherol levels, SOD activity and plasma lipid profile, correlates with those expected if the alteration derived from hepatic damage. The alterated plasma paramenters together with MC-LR determination could be used as biomarkers, helpful tools in screening and epidemiological studies.
format Articulo
Articulo
author Sedan, Daniela Yazmine
Giannuzzi, Leda
Rosso, Lorena
Marra, Carlos Alberto
Andrinolo, Darío
author_facet Sedan, Daniela Yazmine
Giannuzzi, Leda
Rosso, Lorena
Marra, Carlos Alberto
Andrinolo, Darío
author_sort Sedan, Daniela Yazmine
title Biomarkers of prolonged exposure to microcystin-LR in mice
title_short Biomarkers of prolonged exposure to microcystin-LR in mice
title_full Biomarkers of prolonged exposure to microcystin-LR in mice
title_fullStr Biomarkers of prolonged exposure to microcystin-LR in mice
title_full_unstemmed Biomarkers of prolonged exposure to microcystin-LR in mice
title_sort biomarkers of prolonged exposure to microcystin-lr in mice
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/120414
work_keys_str_mv AT sedandanielayazmine biomarkersofprolongedexposuretomicrocystinlrinmice
AT giannuzzileda biomarkersofprolongedexposuretomicrocystinlrinmice
AT rossolorena biomarkersofprolongedexposuretomicrocystinlrinmice
AT marracarlosalberto biomarkersofprolongedexposuretomicrocystinlrinmice
AT andrinolodario biomarkersofprolongedexposuretomicrocystinlrinmice
bdutipo_str Repositorios
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