Clinical and microbiological features of bacteremia caused by Enterococcus faecalis

Introduction: Enterococcus faecalis is a frequent etiologic agent of invasive infections in hospitalized patients. The aim of this study was to analyze clinical and microbiological features of bacteremia caused by E. faecalis. Methodology: Between 2011 and 2013, significant bacteremia caused by E....

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ceci, Mónica, Delpech, Gastón, Sparo, Mónica Delfina, Mezzina, Vito, Sánchez Bruni, Sergio, Baldaccini, Beatriz
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Médicas
Bacteremia
E. faecalis
Hospital
Virulence determinants
Co-morbidity
Mortality
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/120413
https://jidc.org/index.php/journal/article/view/26623628
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-120413
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Bacteremia
E. faecalis
Hospital
Virulence determinants
Co-morbidity
Mortality
spellingShingle Ciencias Médicas
Bacteremia
E. faecalis
Hospital
Virulence determinants
Co-morbidity
Mortality
Ceci, Mónica
Delpech, Gastón
Sparo, Mónica Delfina
Mezzina, Vito
Sánchez Bruni, Sergio
Baldaccini, Beatriz
Clinical and microbiological features of bacteremia caused by Enterococcus faecalis
topic_facet Ciencias Médicas
Bacteremia
E. faecalis
Hospital
Virulence determinants
Co-morbidity
Mortality
description Introduction: Enterococcus faecalis is a frequent etiologic agent of invasive infections in hospitalized patients. The aim of this study was to analyze clinical and microbiological features of bacteremia caused by E. faecalis. Methodology: Between 2011 and 2013, significant bacteremia caused by E. faecalis in hospitalized patients was studied. Patient characteristics, comorbid conditions, and 14-day mortality were recorded. Virulence genes esp, gelE, and cylA; opsonophagocytosis resistance; resistance to bactericidal effect of normal serum; beta lactamase production; and susceptibility to ampicillin, vancomycin, teicoplanin, gentamicin, and streptomycin were investigated. Results: E. faecalis strains were recovered from 33 bacteremic patients. Polymicrobial bacteremia was diagnosed in 2 patients; 10 patients died. Virulence genes were found in strains from both deceased patients and survivors. Sources of bacteremia included urinary tract infections (36.4%), vascular catheters (15.1%), abscesses (9.1%), and unknown (48.5%). Underlying diseases included cancer (30.3%), diabetes (36.4%), cirrhosis (6.1%), renal (36.4%), and chronic obstructive pulmonary disease (2.0%). Co-morbidities included alcohol use (26.1%); glucocorticoid therapy (19.0%); prior antibiotic therapy (60.6%); and central venous (21.2%), arterial (12.1%), and urinary (63.6%) catheters. Also, 57.6% of patients came from the intensive care unit (ICU); 33.3% had mechanical ventilation. Significant mortality-associated conditions included polymicrobial bacteremia, oncological disease, APACHE II score ≥ 20, ICU stay, renal disease, central venous catheter, and mechanical ventilation. Conclusions: Outcome of patients was associated with their status and not with the presence of virulence genes in E. faecalis strains. A significant percentage of bacteremia had undetermined origin. An alternate origin may be the gastrointestinal tract, through translocation.
format Articulo
Articulo
author Ceci, Mónica
Delpech, Gastón
Sparo, Mónica Delfina
Mezzina, Vito
Sánchez Bruni, Sergio
Baldaccini, Beatriz
author_facet Ceci, Mónica
Delpech, Gastón
Sparo, Mónica Delfina
Mezzina, Vito
Sánchez Bruni, Sergio
Baldaccini, Beatriz
author_sort Ceci, Mónica
title Clinical and microbiological features of bacteremia caused by Enterococcus faecalis
title_short Clinical and microbiological features of bacteremia caused by Enterococcus faecalis
title_full Clinical and microbiological features of bacteremia caused by Enterococcus faecalis
title_fullStr Clinical and microbiological features of bacteremia caused by Enterococcus faecalis
title_full_unstemmed Clinical and microbiological features of bacteremia caused by Enterococcus faecalis
title_sort clinical and microbiological features of bacteremia caused by enterococcus faecalis
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/120413
https://jidc.org/index.php/journal/article/view/26623628
work_keys_str_mv AT cecimonica clinicalandmicrobiologicalfeaturesofbacteremiacausedbyenterococcusfaecalis
AT delpechgaston clinicalandmicrobiologicalfeaturesofbacteremiacausedbyenterococcusfaecalis
AT sparomonicadelfina clinicalandmicrobiologicalfeaturesofbacteremiacausedbyenterococcusfaecalis
AT mezzinavito clinicalandmicrobiologicalfeaturesofbacteremiacausedbyenterococcusfaecalis
AT sanchezbrunisergio clinicalandmicrobiologicalfeaturesofbacteremiacausedbyenterococcusfaecalis
AT baldaccinibeatriz clinicalandmicrobiologicalfeaturesofbacteremiacausedbyenterococcusfaecalis
bdutipo_str Repositorios
_version_ 1764820449882013696

Ejemplares similares