Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells

Linalool and 1,8-cineole are plant-derived isoprenoids with anticancer activities in lung cancer cells, nevertheless, the cellular and molecular mechanisms of action remain poorly understood. The purpose of this study was to determine the anticancer mechanisms of action of linalool and 1,8-cineole i...

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Autores principales: Rodenak Kladniew, Boris Emilio, Castro, María Agustina, Crespo, Rosana, Galle, Marianela, García de Bravo, Margarita María
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Ciencias Médicas
Linalool
1,8-Cineole
Non-small lung cancer cells
Cytostatic effects
Reactive oxygen species
Cell migration
Chemosensitizers
Cell biology
Cell culture
Cytotoxicity
Bioactive plant product
Pharmaceutical science
Natural product
Biochemistry
Oxidative stress
Cancer research
Chemotherapy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/119509
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-119509
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Linalool
1,8-Cineole
Non-small lung cancer cells
Cytostatic effects
Reactive oxygen species
Cell migration
Chemosensitizers
Cell biology
Cell culture
Cytotoxicity
Bioactive plant product
Pharmaceutical science
Natural product
Biochemistry
Oxidative stress
Cancer research
Chemotherapy
spellingShingle Ciencias Médicas
Linalool
1,8-Cineole
Non-small lung cancer cells
Cytostatic effects
Reactive oxygen species
Cell migration
Chemosensitizers
Cell biology
Cell culture
Cytotoxicity
Bioactive plant product
Pharmaceutical science
Natural product
Biochemistry
Oxidative stress
Cancer research
Chemotherapy
Rodenak Kladniew, Boris Emilio
Castro, María Agustina
Crespo, Rosana
Galle, Marianela
García de Bravo, Margarita María
Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
topic_facet Ciencias Médicas
Linalool
1,8-Cineole
Non-small lung cancer cells
Cytostatic effects
Reactive oxygen species
Cell migration
Chemosensitizers
Cell biology
Cell culture
Cytotoxicity
Bioactive plant product
Pharmaceutical science
Natural product
Biochemistry
Oxidative stress
Cancer research
Chemotherapy
description Linalool and 1,8-cineole are plant-derived isoprenoids with anticancer activities in lung cancer cells, nevertheless, the cellular and molecular mechanisms of action remain poorly understood. The purpose of this study was to determine the anticancer mechanisms of action of linalool and 1,8-cineole in lung adenocarcinoma A549 cells. Linalool (0–2.0 mM) and 1,8-cineole (0–8.0 mM) inhibited cell proliferation by inducing G0/G1 and/or G2/M cell cycle arrest without affecting cell viability of normal lung WI-38 cells. None of the two monoterpenes were able to induce apoptosis, as observed by the lack of caspase-3 and caspase-9 activation, PARP cleavage, and DNA fragmentation. Linalool, but not 1,8-cineole, increased reactive oxygen species production and mitochondrial membrane potential depolarization. Reactive oxygen species were involved in cell growth inhibition and mitochondrial depolarization induced by linalool since the antioxidant N-acetyl-L-cysteine prevented both effects. Besides, linalool (2.0 mM) and 1,8-cineole (8.0 mM) inhibited A549 cell migration. The combination of each monoterpene with simvastatin increased the G0/G1 cell cycle arrest and sensitized cells to apoptosis compared with simvastatin alone. Our results showed that both monoterpenes might be promising anticancer agents with antiproliferative, anti-metastatic, and sensitizer properties for lung cancer therapy.
format Articulo
Articulo
author Rodenak Kladniew, Boris Emilio
Castro, María Agustina
Crespo, Rosana
Galle, Marianela
García de Bravo, Margarita María
author_facet Rodenak Kladniew, Boris Emilio
Castro, María Agustina
Crespo, Rosana
Galle, Marianela
García de Bravo, Margarita María
author_sort Rodenak Kladniew, Boris Emilio
title Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
title_short Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
title_full Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
title_fullStr Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
title_full_unstemmed Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
title_sort anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer a549 cells
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/119509
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