Modulation of Cox-1, 5-, 12- and 15-Lox by Popular Herbal Remedies Used in Southern Italy Against Psoriasis and Other Skin Diseases

Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids. We here assessed their in vitro effects upon 5-, 12-, 15-LOX and COX-...

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Autores principales: Bader, Ammar, Martini, Francesca, Schinella, Guillermo Raúl, Ríos, José Luis, Prieto, José M.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Médicas
Herbal medicine
Psoriasis
Leukotrienes
Prostaglandins
Asteraceae
Acanthaceae
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/119197
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-119197
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Herbal medicine
Psoriasis
Leukotrienes
Prostaglandins
Asteraceae
Acanthaceae
spellingShingle Ciencias Médicas
Herbal medicine
Psoriasis
Leukotrienes
Prostaglandins
Asteraceae
Acanthaceae
Bader, Ammar
Martini, Francesca
Schinella, Guillermo Raúl
Ríos, José Luis
Prieto, José M.
Modulation of Cox-1, 5-, 12- and 15-Lox by Popular Herbal Remedies Used in Southern Italy Against Psoriasis and Other Skin Diseases
topic_facet Ciencias Médicas
Herbal medicine
Psoriasis
Leukotrienes
Prostaglandins
Asteraceae
Acanthaceae
description Acanthus mollis (Acanthaceae), Achillea ligustica, Artemisia arborescens and Inula viscosa (Asteraceae) are used in Southern Italy against psoriasis and other skin diseases that occur with an imbalanced production of eicosanoids. We here assessed their in vitro effects upon 5-, 12-, 15-LOX and COX-1 enzymes as well as NFκB activation in intact cells as their possible therapeutic targets. All methanol crude extracts inhibited both 5-LOX and COX-1 activities under 200 μg/mL, without significant effects on the 12-LOX pathway or any relevant in vitro free radical scavenging activity. NFκB activation was prevented by all extracts but A. mollis. Interestingly, A. ligustica, A. arborescens and A. mollis increased the biosynthesis of 15(S)-HETE, an anti-inflammatory eicosanoid. A. ligustica (IC50 = 49.5 μg/mL) was superior to Silybum marianum (IC50 = 147.8 μg/mL), which we used as antipsoriatic herbal medicine of reference. Its n-hexane, dichloromethane and ethyl acetate fractions had also inhibitory effects on the LTB4 biosynthesis (IC50s = 9.6, 20.3 and 68 μg/mL, respectively) evidencing that the apolar extracts of A. ligustica are promising active herbal ingredients for future phytotherapeutical products targeting psoriasis.
format Articulo
Articulo
author Bader, Ammar
Martini, Francesca
Schinella, Guillermo Raúl
Ríos, José Luis
Prieto, José M.
author_facet Bader, Ammar
Martini, Francesca
Schinella, Guillermo Raúl
Ríos, José Luis
Prieto, José M.
author_sort Bader, Ammar
title Modulation of Cox-1, 5-, 12- and 15-Lox by Popular Herbal Remedies Used in Southern Italy Against Psoriasis and Other Skin Diseases
title_short Modulation of Cox-1, 5-, 12- and 15-Lox by Popular Herbal Remedies Used in Southern Italy Against Psoriasis and Other Skin Diseases
title_full Modulation of Cox-1, 5-, 12- and 15-Lox by Popular Herbal Remedies Used in Southern Italy Against Psoriasis and Other Skin Diseases
title_fullStr Modulation of Cox-1, 5-, 12- and 15-Lox by Popular Herbal Remedies Used in Southern Italy Against Psoriasis and Other Skin Diseases
title_full_unstemmed Modulation of Cox-1, 5-, 12- and 15-Lox by Popular Herbal Remedies Used in Southern Italy Against Psoriasis and Other Skin Diseases
title_sort modulation of cox-1, 5-, 12- and 15-lox by popular herbal remedies used in southern italy against psoriasis and other skin diseases
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/119197
work_keys_str_mv AT baderammar modulationofcox1512and15loxbypopularherbalremediesusedinsouthernitalyagainstpsoriasisandotherskindiseases
AT martinifrancesca modulationofcox1512and15loxbypopularherbalremediesusedinsouthernitalyagainstpsoriasisandotherskindiseases
AT schinellaguillermoraul modulationofcox1512and15loxbypopularherbalremediesusedinsouthernitalyagainstpsoriasisandotherskindiseases
AT riosjoseluis modulationofcox1512and15loxbypopularherbalremediesusedinsouthernitalyagainstpsoriasisandotherskindiseases
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bdutipo_str Repositorios
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