EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans

Objective: Rapid eye movement (REM) sleep has a suppressing effect on epileptic activity. This effect might be directly related to neuronal desynchronization mediated by cholinergic neurotransmission.We investigated whether interictal epileptiform discharges (IEDs) and high frequency oscillations—a...

Descripción completa

Detalles Bibliográficos
Autores principales: Frauscher, Birgit, Ellenrieder, Nicolás von, Dubeau, François, Gotman, Jean
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Ingeniería
Epilepsy
Intracerebral EEG
Polysomnography
High-frequency oscillations
Sleep
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/119183
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-119183
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ingeniería
Epilepsy
Intracerebral EEG
Polysomnography
High-frequency oscillations
Sleep
spellingShingle Ingeniería
Epilepsy
Intracerebral EEG
Polysomnography
High-frequency oscillations
Sleep
Frauscher, Birgit
Ellenrieder, Nicolás von
Dubeau, François
Gotman, Jean
EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans
topic_facet Ingeniería
Epilepsy
Intracerebral EEG
Polysomnography
High-frequency oscillations
Sleep
description Objective: Rapid eye movement (REM) sleep has a suppressing effect on epileptic activity. This effect might be directly related to neuronal desynchronization mediated by cholinergic neurotransmission.We investigated whether interictal epileptiform discharges (IEDs) and high frequency oscillations—a biomarker of the epileptogenic zone —are evenly distributed across phasic and tonic REM sleep.We hypothesized that IEDs aremore suppressed during phasic REM sleep because of additional cholinergic drive. Methods: Twelve patients underwent polysomnography during long-term combined scalp-intracerebral electroencephalography (EEG) recording. After sleep staging in the scalp EEG, we identified segments of REM sleep with rapid eye movements (phasic REM) and segments of REM sleep without rapid eye movements (tonic REM). In the intracerebral EEG, we computed the power in frequencies <30 Hz and from 30 to 500 Hz, and marked IEDs, ripples (>80 Hz) and fast ripples (>250 Hz). We grouped the intracerebral channels into channels in the seizure-onset zone (SOZ), the exclusively irritative zone (EIZ), and the normal zone (NoZ). Results: Power in frequencies <30 Hz was lower during phasic than tonic REM sleep (p < 0.001), most likely reflecting increased desynchronization. IEDs, ripples and fast ripples, were less frequent during phasic than tonic REM sleep (phasic REM sleep: 39% of spikes, 35% of ripples, 18% of fast ripples, tonic REM sleep: 61% of spikes, 65% of ripples, 82% of fast ripples; p < 0.001). In contrast to ripples in the epileptogenic zone, physiologic ripples were more abundant during phasic REM sleep (phasic REM sleep: 73% in NoZ, 30% in EIZ, 28% in SOZ, tonic REM sleep: 27% in NoZ, 70% in EIZ, 72% in SOZ; p < 0.001). Significance: Phasic REM sleep has an enhanced suppressive effect on IEDs, corroborating the role of EEG desynchronization in the suppression of interictal epileptic activity. In contrast, physiologic ripples were increased during phasic REM sleep, possibly reflecting REM-related memory consolidation and dreaming.
format Articulo
Articulo
author Frauscher, Birgit
Ellenrieder, Nicolás von
Dubeau, François
Gotman, Jean
author_facet Frauscher, Birgit
Ellenrieder, Nicolás von
Dubeau, François
Gotman, Jean
author_sort Frauscher, Birgit
title EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans
title_short EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans
title_full EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans
title_fullStr EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans
title_full_unstemmed EEG desynchronization during phasic REM sleep suppresses interictal epileptic activity in humans
title_sort eeg desynchronization during phasic rem sleep suppresses interictal epileptic activity in humans
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/119183
work_keys_str_mv AT frauscherbirgit eegdesynchronizationduringphasicremsleepsuppressesinterictalepilepticactivityinhumans
AT ellenriedernicolasvon eegdesynchronizationduringphasicremsleepsuppressesinterictalepilepticactivityinhumans
AT dubeaufrancois eegdesynchronizationduringphasicremsleepsuppressesinterictalepilepticactivityinhumans
AT gotmanjean eegdesynchronizationduringphasicremsleepsuppressesinterictalepilepticactivityinhumans
bdutipo_str Repositorios
_version_ 1764820447988285440

Ejemplares similares